PSYCH OpenIR  > 中国科学院心理健康重点实验室
Sex Differences in the Prevalence and Clinical Features of Comorbid Depressive Symptoms in Never-Treated Chinese Patients With First-Episode Schizophrenia
Wang, Dong-Mei1; Zhang, Guang-Ya2; Du, Xiang-Dong2; Jia, Qiu-Fang2; Qian, Zheng-Kang2; Yin, Guang-Zhong2; Chen, Chun3; Xiu, Mei-Hong3; Ning, Yu-Ping4,5; Huang, Xing-Bing4; Wu, Feng-Chun4,5; Zhang, Xiang-Yang1,4
2019-11-01
Source PublicationJOURNAL OF CLINICAL PSYCHIATRY
ISSN0160-6689
Volume80Issue:6Pages:7
Abstract

Background: Many studies have indicated a sex-specific effect in many aspects of schizophrenia. The presence of depressive symptomatology exists in all phases of schizophrenia. The aim of this study is to investigate the sex differences in the proportion of comorbid depressive symptoms and sex-specific relationships between depressive symptoms and clinical correlates in never-treated Chinese patients with first-episode schizophrenia (NTFE patients), which have not been reported yet. Methods:Via a cross-sectional design, 240 NTFE inpatients (male/ female =111/129) between ages 16 and 45 years and meeting DSM-IV-TR criteria of schizophrenia were recruited. The Positive and Negative Syndrome Scale (PANSS) was used for the psychopathology, and the 17-item Hamilton Depression Rating Scale (HDRS-17) for the comorbid depressive symptoms. This study was conducted from June 2013 to December 2015. Results: The proportion of patients with depressive symptoms (total score on HORS-17 >= 8) in men was significantly higher than in women (male: 62.2%, female: 48.1%; chi(2)(1) =4.28, P= .039). Male patients had significantly greater depressive symptoms as shown on the HDRS-17 than female patients (t(1, 238)= 2.75, P= .006). Further, we found that age, the age at onset, smoking rate, and PANSS total and general psychopathology, negative symptoms, and cognitive factor subscores favored significant sex differences in female patients (all P <.05). Interestingly, we found sex differences in the correlation between the HORS-17 score and clinical phenotype, showing that in male patients, the PANSS general psychopathology subscore (beta=0.75, t= 7.72, P<.001) and total score (beta =0.44, t=4.81, P<.001) significantly predicted the HDRS-17 total score, while in female patients, the PANSS general psychopathology subscore (beta=0.74, t= 8.45, P < .001), total score (beta=0.47, t= 5.71, P < .001), and cognitive factor subscore ((3=0.24, t= 2.60, P < .001) significantly predicted the HDRS-17 total score. Conclusions: Our results indicate sex differences in the frequency and severity of comorbid depressive symptoms and in associations between depressive symptoms and clinical correlates in NTFE patients.

DOI10.4088/JCP.19m12780
Indexed BySCI
Language英语
Funding OrganizationCAS Program ; Science and Technology Program of Guangdong ; Science and Technology Program of Guangzhou ; Suzhou Key Project (Psychiatry) ; Suzhou Key Medical Center for Psychiatric Diseases ; Key Laboratory of Mental Health, Institute of Psychology, CAS
Funding ProjectCAS Program ; Science and Technology Program of Guangdong[2016A020216004] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangzhou[201807010064] ; Suzhou Key Project (Psychiatry)[Szxk201515] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Key Laboratory of Mental Health, Institute of Psychology, CAS
WOS Research AreaPsychology ; Psychiatry
WOS SubjectPsychology, Clinical ; Psychiatry
WOS IDWOS:000517803900008
PublisherPHYSICIANS POSTGRADUATE PRESS
WOS KeywordNEGATIVE SYNDROME SCALE ; QUALITY-OF-LIFE ; GENDER-DIFFERENCES ; PSYCHOSIS ; ONSET ; AGE ; ASSOCIATION ; INPATIENTS ; DISORDERS ; COGNITION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31401
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiang-Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Soochow Univ, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
3.Beijing Huilongguan Hosp, Beijing, Peoples R China
4.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Huiai Hosp, Guangzhou, Peoples R China
5.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Dong-Mei,Zhang, Guang-Ya,Du, Xiang-Dong,et al. Sex Differences in the Prevalence and Clinical Features of Comorbid Depressive Symptoms in Never-Treated Chinese Patients With First-Episode Schizophrenia[J]. JOURNAL OF CLINICAL PSYCHIATRY,2019,80(6):7.
APA Wang, Dong-Mei.,Zhang, Guang-Ya.,Du, Xiang-Dong.,Jia, Qiu-Fang.,Qian, Zheng-Kang.,...&Zhang, Xiang-Yang.(2019).Sex Differences in the Prevalence and Clinical Features of Comorbid Depressive Symptoms in Never-Treated Chinese Patients With First-Episode Schizophrenia.JOURNAL OF CLINICAL PSYCHIATRY,80(6),7.
MLA Wang, Dong-Mei,et al."Sex Differences in the Prevalence and Clinical Features of Comorbid Depressive Symptoms in Never-Treated Chinese Patients With First-Episode Schizophrenia".JOURNAL OF CLINICAL PSYCHIATRY 80.6(2019):7.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Dong-Mei]'s Articles
[Zhang, Guang-Ya]'s Articles
[Du, Xiang-Dong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Dong-Mei]'s Articles
[Zhang, Guang-Ya]'s Articles
[Du, Xiang-Dong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Dong-Mei]'s Articles
[Zhang, Guang-Ya]'s Articles
[Du, Xiang-Dong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.