PSYCH OpenIR  > 中国科学院心理健康重点实验室
High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia
Guan, Heng Yong1; Zhao, Jian Min1; Wang, Ke Qiang1; Su, Xiu Ru1; Pan, Yan Fen1; Guo, Jin Ming1; Jiang, Long1; Wang, Yu Hong1; Liu, Hong Yu1; Sun, Shi Guang1; Wu, Hao Ran1; Ren, Yan Ping2,3; Geng, Han Song1; Liu, Xiao Wen1; Yu, Hui Jing1; Wei, Bao Chun1; Li, Xi Po1; Wu, Hanjing Emily4; Tan, Shu Ping5; Xiu, Mei Hong5; Zhang, Xiang Yang6,7
First AuthorGuan, Heng Yong
Correspondent Emailmei hong xiu (xiumeihong97@163.com) ; xiang yang zhang (zhangxy@psych.ac.cn)
2020-02-25
Source PublicationTRANSLATIONAL PSYCHIATRY
ISSN2158-3188
Subtypearticle
Volume10Issue:1Pages:9
QuartileQ1
Contribution Rank7
Abstract

Cognitive impairment is a central aspect of schizophrenia (SCZ) that occurs at the onset of the disease and is related to poor social function and outcome in patients with SCZ. Recent literatures have revealed repetitive transcranial magnetic stimulation (rTMS) to be one of the efficient medical interventions for cognitive impairments. However, no study has been conducted to investigate the treatment effectiveness of 20 Hz rTMS with neuronavigation system administered to the left dorsolateral prefrontal cortex (DLPFC) in patients with schizophrenia. In this randomized, double-blind and sham-controlled study, 56 patients were enrolled in 20 Hz rTMS (n = 28) or sham stimulation (n = 28) over left DLPFC for 8 weeks. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to measure the cognitive function at baseline and after 8 weeks of rTMS treatment. The positive and negative syndrome scales (PANSS) was performed to assess the clinical symptoms at baseline, after 2-week treatment, 4-week treatment, 6-week treatment, and 8-week treatment. Totally, 15 subjects (seven in active group and eight in sham group) dropped out during the trial and the main findings were from completed 41 patients. At 2 weeks, 4 weeks, and 6 weeks, there were no significant differences in PANSS total score and subscores between the sham and treatment groups. At 8 weeks, the 20 Hz rTMS significantly increased the immediate memory score compared with the sham. Furthermore, the improvement in the immediate memory score was correlated with the decrease in the excitement factor score of the patients with SCZ. Our results suggest that 20 Hz rTMS appears to be an effective treatment for improving the cognitive performance and reducing the clinical symptoms of patients with SCZ.

DOI10.1038/s41398-020-0745-6
Indexed BySCI
Language英语
Funding OrganizationScientific and Technological Program of Hebei
Funding ProjectScientific and Technological Program of Hebei[20150593]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000519575200002
PublisherNATURE PUBLISHING GROUP
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; AUDITORY VERBAL HALLUCINATIONS ; PREDOMINANT NEGATIVE SYMPTOMS ; MAJOR DEPRESSION ; PREFRONTAL CORTEX ; EFFICACY ; METAANALYSIS ; MULTISITE ; DOPAMINE ; SAFETY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31410
Collection中国科学院心理健康重点实验室
Corresponding AuthorXiu, Mei Hong; Zhang, Xiang Yang
Affiliation1.Hebei Prov Rong Jun Hosp, Baoding, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
4.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Peking Univ, Beijing Huilongguan Hosp, Huilongguan Clin Med Sch, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guan, Heng Yong,Zhao, Jian Min,Wang, Ke Qiang,et al. High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):9.
APA Guan, Heng Yong.,Zhao, Jian Min.,Wang, Ke Qiang.,Su, Xiu Ru.,Pan, Yan Fen.,...&Zhang, Xiang Yang.(2020).High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia.TRANSLATIONAL PSYCHIATRY,10(1),9.
MLA Guan, Heng Yong,et al."High-frequency neuronavigated rTMS effect on clinical symptoms and cognitive dysfunction: a pilot double-blind, randomized controlled study in Veterans with schizophrenia".TRANSLATIONAL PSYCHIATRY 10.1(2020):9.
Files in This Item:
File Name/Size DocType Version Access License
High-frequency neuro(458KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guan, Heng Yong]'s Articles
[Zhao, Jian Min]'s Articles
[Wang, Ke Qiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guan, Heng Yong]'s Articles
[Zhao, Jian Min]'s Articles
[Wang, Ke Qiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guan, Heng Yong]'s Articles
[Zhao, Jian Min]'s Articles
[Wang, Ke Qiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.