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Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study | |
Wang, Ya1,2,3; Harding, Ian H.1,2,4,5; Testa, Renee1,2,5,6,7; Tonge, Bruce8; Jones, Harvey9; Seal, Marc10; Ross, Nola6; Chan, Raymond C. K.3; van Beurden, Florian1,2; Abu-Akel, Ahmad11; Skafidas, Efstratios1,2,12; Pantelis, Christos1,2,12,13 | |
第一作者 | Wang, Ya |
通讯作者邮箱 | cpant@unimelb.edu.au |
心理所单位排序 | 3 |
摘要 | Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in children (SDc) is less well described. This study examined brain morphological and functional connectivity abnormalities in SDc (12 SDc and 9 typically developing children), focusing on the default mode and executive control brain networks. Results indicated that SDc is associated with reduced grey matter volume (GMV) in superior and medial frontal gyri, and increased resting-state functional connectivity between the superior frontal gyrus and inferior parietal lobule, compared to typically developing children (cluster-level FWE-corrected p < 0.05). The brain structure abnormality (GMV in left superior frontal gyrus) was correlated with clinical symptoms in SDc (r = -0.66, p = 0.026) and functional connectivity abnormality was correlated with extra-dimensional shifting impairments in all participants (r = 0.62, p = 0.011), suggesting their contribution to the underlying mechanisms of clinical presentation. These preliminary results motivate further work to characterize the neural basis of SDc and its significance as a risk factor for later psychosis. |
2020-03-18 | |
DOI | 10.1038/s41537-020-0095-7 |
发表期刊 | NPJ SCHIZOPHRENIA |
卷号 | 6期号:1页码:4 |
收录类别 | SCI |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | PERSONALITY-DISORDER ; DEFAULT MODE ; WORKING-MEMORY ; SCHIZOPHRENIA ; NETWORK ; CONNECTIVITY ; CHILDHOOD ; PSYCHOSIS ; ONSET ; RISK |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000520616600001 |
WOS分区 | Q1 |
Q分类 | Q1 |
资助机构 | University of Melbourne Research Grant Support Scheme ; NHMRC Senior Principal Research Fellowship ; Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US) ; Lundbeck Foundation ; NHMRC Early Career Fellowship ; China Scholarship Council |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31461 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Pantelis, Christos |
作者单位 | 1.Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Carlton, Vic, Australia 2.Melbourne Hlth, Carlton, Vic, Australia 3.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing, Peoples R China 4.Monash Univ, Turner Inst Brain & Mental Hlth, Clayton, Vic, Australia 5.Monash Univ, Sch Psychol Sci, Clayton, Vic, Australia 6.Child & Adolescent Neuropsychol Grp, East Melbourne, Vic, Australia 7.Royal Childrens Hosp, Mental Hlth Dept, Parkville, Vic, Australia 8.Monash Univ, Sch Clin Sci, Ctr Dev Psychiat & Psychol, Clayton, Vic, Australia 9.Epworth HealthCare, Dept Psychol, Richmond, Vic, Australia 10.Murdoch Childrens Res Inst, Parkville, Vic, Australia 11.Univ Lausanne, Inst Psychol, Lausanne, Switzerland 12.Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic, Australia 13.Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia |
第一作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Wang, Ya,Harding, Ian H.,Testa, Renee,et al. Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study[J]. NPJ SCHIZOPHRENIA,2020,6(1):4. |
APA | Wang, Ya.,Harding, Ian H..,Testa, Renee.,Tonge, Bruce.,Jones, Harvey.,...&Pantelis, Christos.(2020).Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study.NPJ SCHIZOPHRENIA,6(1),4. |
MLA | Wang, Ya,et al."Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study".NPJ SCHIZOPHRENIA 6.1(2020):4. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Wang_etal_2020.npj_s(777KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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