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Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study
Wang, Ya1,2,3; Harding, Ian H.1,2,4,5; Testa, Renee1,2,5,6,7; Tonge, Bruce8; Jones, Harvey9; Seal, Marc10; Ross, Nola6; Chan, Raymond C. K.3; van Beurden, Florian1,2; Abu-Akel, Ahmad11; Skafidas, Efstratios1,2,12; Pantelis, Christos1,2,12,13
First AuthorWang, Ya
Contribution Rank3
Abstract

Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in children (SDc) is less well described. This study examined brain morphological and functional connectivity abnormalities in SDc (12 SDc and 9 typically developing children), focusing on the default mode and executive control brain networks. Results indicated that SDc is associated with reduced grey matter volume (GMV) in superior and medial frontal gyri, and increased resting-state functional connectivity between the superior frontal gyrus and inferior parietal lobule, compared to typically developing children (cluster-level FWE-corrected p < 0.05). The brain structure abnormality (GMV in left superior frontal gyrus) was correlated with clinical symptoms in SDc (r = -0.66, p = 0.026) and functional connectivity abnormality was correlated with extra-dimensional shifting impairments in all participants (r = 0.62, p = 0.011), suggesting their contribution to the underlying mechanisms of clinical presentation. These preliminary results motivate further work to characterize the neural basis of SDc and its significance as a risk factor for later psychosis.

2020-03-18
Language英语
DOI10.1038/s41537-020-0095-7
Source PublicationNPJ SCHIZOPHRENIA
Volume6Issue:1Pages:4
Indexed BySCI
Funding ProjectUniversity of Melbourne Research Grant Support Scheme[1452755] ; NHMRC Senior Principal Research Fellowship[628386] ; NHMRC Senior Principal Research Fellowship[1105825] ; Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US)[18722] ; Lundbeck Foundation[R246-2016-3237] ; NHMRC Early Career Fellowship[1106533] ; China Scholarship Council
PublisherNATURE PUBLISHING GROUP
WOS KeywordPERSONALITY-DISORDER ; DEFAULT MODE ; WORKING-MEMORY ; SCHIZOPHRENIA ; NETWORK ; CONNECTIVITY ; CHILDHOOD ; PSYCHOSIS ; ONSET ; RISK
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000520616600001
QuartileQ4
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31461
Collection中国科学院心理健康重点实验室
Corresponding AuthorPantelis, Christos
Affiliation1.Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Carlton, Vic, Australia
2.Melbourne Hlth, Carlton, Vic, Australia
3.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing, Peoples R China
4.Monash Univ, Turner Inst Brain & Mental Hlth, Clayton, Vic, Australia
5.Monash Univ, Sch Psychol Sci, Clayton, Vic, Australia
6.Child & Adolescent Neuropsychol Grp, East Melbourne, Vic, Australia
7.Royal Childrens Hosp, Mental Hlth Dept, Parkville, Vic, Australia
8.Monash Univ, Sch Clin Sci, Ctr Dev Psychiat & Psychol, Clayton, Vic, Australia
9.Epworth HealthCare, Dept Psychol, Richmond, Vic, Australia
10.Murdoch Childrens Res Inst, Parkville, Vic, Australia
11.Univ Lausanne, Inst Psychol, Lausanne, Switzerland
12.Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic, Australia
13.Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia
First Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Wang, Ya,Harding, Ian H.,Testa, Renee,et al. Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study[J]. NPJ SCHIZOPHRENIA,2020,6(1):4.
APA Wang, Ya.,Harding, Ian H..,Testa, Renee.,Tonge, Bruce.,Jones, Harvey.,...&Pantelis, Christos.(2020).Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study.NPJ SCHIZOPHRENIA,6(1),4.
MLA Wang, Ya,et al."Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study".NPJ SCHIZOPHRENIA 6.1(2020):4.
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