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Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain
Wang, Ting1; Lian, Zhiyun2; Wu, Xi1; Kong, Yazhuo3; Zhou, Hongyu2; Wei, Min1
First AuthorWang, Ting
Correspondent Emailzhouhy@scu.edu.cn (h. zhou) ; weimin@cuit.edu.cn (m. wei).
Contribution Rank3
Abstract

Neuromyelitis optica (NMO) is a disease characterised by severe relapses of optic neuritis and longitudinally extensive transverse myelitis and it has a strong female predilection. Pain is one of the most typical symptom in NMO. However, few studies have been conducted to examine the neuropathic pain mechanism of NMO patients or gender-specific effects using magnetic resonance imaging technique. A total of 38 female patients with NMO, 28 with pain (NMOWP) and 10 without pain (NMOWoP), were classified using the Brief Pain Inventory (BPI); 22 healthy females were also recruited. We used the FSL Image Registration and Segmentation Toolbox (FIRST) for subcortical region volumes quantifications, and voxel-based morphometry analysis for cortical gray matter (GM) volume, to examine the brain morphology in NMOWP patients. In addition, correlation test between structural measurements of NMO patients and clinical indexes was also performed. The results showed: 1) no significant differences in cortical GM density between the NMOWP and NMOWoP groups; 2) significantly smaller hippocampus and pallidum volumes in the NMOWP group compared with the NMOWoP group; 3) significant negative correlation between the average BPI and volumes of the accumbens nucleus and thalamus in NMO patients. These results revealed that structural abnormality exists in NMO female patients who have pain, with significant implications for our understanding of the brain morphology in NMO patients with pain.

KeywordNeuromyelitis optica Neuropathic pain Voxel-based morphometry Magnetic resonance imaging
2020
Language英语
DOI10.1016/j.msard.2019.101432
Source PublicationMULTIPLE SCLEROSIS AND RELATED DISORDERS
ISSN2211-0348
Volume37Pages:6
Subtypearticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation[61806029] ; Chengdu University of Information Engineering Research Fund[KYTZ201719] ; Project of Sichuan Provincial Education Hall[18ZA0089] ; Project of Sichuan Provincial Education Hall[2018Z065]
PublisherELSEVIER SCI LTD
WOS KeywordQUALITY-OF-LIFE ; MULTIPLE-SCLEROSIS ; DIAGNOSTIC-CRITERIA ; BRAIN ABNORMALITIES ; SPECTRUM DISORDER ; THALAMIC NEURONS ; MOTOR CORTEX ; MRI ; PROJECTION ; INPUT
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000521647200013
QuartileQ2
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31494
Collection中国科学院行为科学重点实验室
Corresponding AuthorZhou, Hongyu; Wei, Min
Affiliation1.Chengdu Univ Informat Technol, Dept Comp Sci, Chengdu, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ting,Lian, Zhiyun,Wu, Xi,et al. Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain[J]. MULTIPLE SCLEROSIS AND RELATED DISORDERS,2020,37:6.
APA Wang, Ting,Lian, Zhiyun,Wu, Xi,Kong, Yazhuo,Zhou, Hongyu,&Wei, Min.(2020).Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain.MULTIPLE SCLEROSIS AND RELATED DISORDERS,37,6.
MLA Wang, Ting,et al."Subcortical structural abnormalities in female neuromyelitis optica patients with neuropathic pain".MULTIPLE SCLEROSIS AND RELATED DISORDERS 37(2020):6.
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