Institutional Repository of Key Laboratory of Mental Health, CAS
Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas | |
Wang, Haixiang1; McGonigal, Aileen2,3; Zhang, Kai4; Guo, Qiang5; Zhang, Bingqing1; Wang, Xiu5; Wang, Xiao6; Lin, Jiuluan1; Song, Xiancheng1; Feng, Qian1; Wang, Siyu1; Wang, Mengyang6; Shao, Xiaoqiu7; Liu, Xiaoyan8; Wang, Liang9,10; Zhou, Wenjing1 | |
第一作者 | Wang, Haixiang |
通讯作者邮箱 | closejeo@hotmail.com ; lwang@psych.ac.cn |
摘要 | Objective Insulo-opercular seizures are characterized by diverse semiology, related to the insula's multiple functional roles and extensive connectivity. We aimed to identify semiologic subgroups and correlate these with insulo-opercular subregions based on connectional architecture. Methods We retrospectively collected a large series of 37 patients with insulo-opercular seizures explored by stereoelectroencephalography (SEEG) from three epilepsy centers. A new human brain atlas (Brainnetome Atlas, BNA) based on both anatomic and functional connections was employed to segment insulo-opercular cortex. Semiology and SEEG changes were carefully reviewed and quantified. Principal component analysis and cluster analysis were used to correlate semiologic characteristics with insulo-opercular subregions. Results Four main semiologic subgroups were identified, organized along an anteroventral to posterodorsal axis based on BNA. Group 1 was characterized by epigastric sensation and/or integrated gestural motor behaviors with or without feelings of fear or rage, involving the anteroventral insular regions and mesial temporal lobes. Group 2 was characterized by auditory sensations and symmetric proximal/axial tonic signs involving the posteroventral temporal operculum. The characteristics of group 3 were orofacial and laryngeal signs, involving the intermediate insulo-opercular regions. The features of group 4 were somatosensory signs followed by nonintegrated gestural motor behaviors and/or asymmetric tonic signs involving the posterodorsal insulo-opercular regions with propagation to the mesial frontal lobes. Thus anteroventral seizure organizations predominantly showed limbic system semiology, whereas more posterodorsal regions were associated with semiology involving mainly the sensorimotor system. Subjective symptoms proved to be particularly discriminating factors. Significance Insulo-opercular seizures can be categorized in terms of clinical semiology and correlate with connectional architecture subregions along an anteroventral-posterodorsal axis in line with the cytoarchitectonic gradient rather than the gyral anatomy of the insula cortex. This provides new insights into facilitating differential diagnosis and presurgical localization but also highlights the importance of considering connectional architecture in determining neural correlates of complex semiologic patterns. |
关键词 | Brainnetome Atlas cluster analysis insular seizure semiology stereoelectroencephalography |
2020-04-21 | |
DOI | 10.1111/epi.16501 |
发表期刊 | EPILEPSIA |
ISSN | 0013-9580 |
页码 | 11 |
收录类别 | SCI |
资助项目 | Natural Science Foundation of China[31771255] ; Natural Science Foundation of China[Z171100000117014] ; Natural Science Foundation of China[XDB32010300] ; Beijing Municipal Science and Technology Commission ; Strategic Priority Research Program of Chinese Academy of Science |
出版者 | WILEY |
WOS关键词 | LOBE EPILEPSY ; CHILDHOOD ; CORTEX |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Clinical Neurology |
WOS记录号 | WOS:000527035700001 |
WOS分区 | Q1 |
Q分类 | Q1 |
资助机构 | Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Strategic Priority Research Program of Chinese Academy of Science |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31534 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Liang; Zhou, Wenjing |
作者单位 | 1.Tsinghua Univ, Epilepsy Ctr, Yuquan Hosp, 5 Shijingshan Rd, Beijing, Peoples R China 2.Aix Marseille Univ, INSERM, INS, Marseille, France 3.Timone Hosp, AP HM, Clin Neurophysiol & Epileptol Dept, Marseille, France 4.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 5.Guangdong Sanjiu Brain Hosp, Epilepsy Ctr, Guangzhou, Peoples R China 6.Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurol, Beijing, Peoples R China 7.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China 8.Peking Univ, Hosp 1, Dept Pediat, Beijing, Peoples R China 9.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China 10.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Haixiang,McGonigal, Aileen,Zhang, Kai,et al. Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas[J]. EPILEPSIA,2020:11. |
APA | Wang, Haixiang.,McGonigal, Aileen.,Zhang, Kai.,Guo, Qiang.,Zhang, Bingqing.,...&Zhou, Wenjing.(2020).Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas.EPILEPSIA,11. |
MLA | Wang, Haixiang,et al."Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas".EPILEPSIA (2020):11. |
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Semiologic subgroups(1820KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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