PSYCH OpenIR  > 中国科学院心理健康重点实验室
Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas
Wang, Haixiang1; McGonigal, Aileen2,3; Zhang, Kai4; Guo, Qiang5; Zhang, Bingqing1; Wang, Xiu5; Wang, Xiao6; Lin, Jiuluan1; Song, Xiancheng1; Feng, Qian1; Wang, Siyu1; Wang, Mengyang6; Shao, Xiaoqiu7; Liu, Xiaoyan8; Wang, Liang9,10; Zhou, Wenjing1
First AuthorWang, Haixiang
Correspondent Emailclosejeo@hotmail.com ; lwang@psych.ac.cn
2020-04-21
Source PublicationEPILEPSIA
ISSN0013-9580
Subtypearticle
Pages11
QuartileQ1
Abstract

Objective Insulo-opercular seizures are characterized by diverse semiology, related to the insula's multiple functional roles and extensive connectivity. We aimed to identify semiologic subgroups and correlate these with insulo-opercular subregions based on connectional architecture. Methods We retrospectively collected a large series of 37 patients with insulo-opercular seizures explored by stereoelectroencephalography (SEEG) from three epilepsy centers. A new human brain atlas (Brainnetome Atlas, BNA) based on both anatomic and functional connections was employed to segment insulo-opercular cortex. Semiology and SEEG changes were carefully reviewed and quantified. Principal component analysis and cluster analysis were used to correlate semiologic characteristics with insulo-opercular subregions. Results Four main semiologic subgroups were identified, organized along an anteroventral to posterodorsal axis based on BNA. Group 1 was characterized by epigastric sensation and/or integrated gestural motor behaviors with or without feelings of fear or rage, involving the anteroventral insular regions and mesial temporal lobes. Group 2 was characterized by auditory sensations and symmetric proximal/axial tonic signs involving the posteroventral temporal operculum. The characteristics of group 3 were orofacial and laryngeal signs, involving the intermediate insulo-opercular regions. The features of group 4 were somatosensory signs followed by nonintegrated gestural motor behaviors and/or asymmetric tonic signs involving the posterodorsal insulo-opercular regions with propagation to the mesial frontal lobes. Thus anteroventral seizure organizations predominantly showed limbic system semiology, whereas more posterodorsal regions were associated with semiology involving mainly the sensorimotor system. Subjective symptoms proved to be particularly discriminating factors. Significance Insulo-opercular seizures can be categorized in terms of clinical semiology and correlate with connectional architecture subregions along an anteroventral-posterodorsal axis in line with the cytoarchitectonic gradient rather than the gyral anatomy of the insula cortex. This provides new insights into facilitating differential diagnosis and presurgical localization but also highlights the importance of considering connectional architecture in determining neural correlates of complex semiologic patterns.

KeywordBrainnetome Atlas cluster analysis insular seizure semiology stereoelectroencephalography
DOI10.1111/epi.16501
Indexed BySCI
Language英语
Funding OrganizationNatural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Strategic Priority Research Program of Chinese Academy of Science
Funding ProjectNatural Science Foundation of China[31771255] ; Natural Science Foundation of China[Z171100000117014] ; Natural Science Foundation of China[XDB32010300] ; Beijing Municipal Science and Technology Commission ; Strategic Priority Research Program of Chinese Academy of Science
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000527035700001
PublisherWILEY
WOS KeywordLOBE EPILEPSY ; CHILDHOOD ; CORTEX
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31534
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Liang; Zhou, Wenjing
Affiliation1.Tsinghua Univ, Epilepsy Ctr, Yuquan Hosp, 5 Shijingshan Rd, Beijing, Peoples R China
2.Aix Marseille Univ, INSERM, INS, Marseille, France
3.Timone Hosp, AP HM, Clin Neurophysiol & Epileptol Dept, Marseille, France
4.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
5.Guangdong Sanjiu Brain Hosp, Epilepsy Ctr, Guangzhou, Peoples R China
6.Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurol, Beijing, Peoples R China
7.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China
8.Peking Univ, Hosp 1, Dept Pediat, Beijing, Peoples R China
9.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China
10.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Haixiang,McGonigal, Aileen,Zhang, Kai,et al. Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas[J]. EPILEPSIA,2020:11.
APA Wang, Haixiang.,McGonigal, Aileen.,Zhang, Kai.,Guo, Qiang.,Zhang, Bingqing.,...&Zhou, Wenjing.(2020).Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas.EPILEPSIA,11.
MLA Wang, Haixiang,et al."Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas".EPILEPSIA (2020):11.
Files in This Item:
File Name/Size DocType Version Access License
Semiologic subgroups(1820KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Haixiang]'s Articles
[McGonigal, Aileen]'s Articles
[Zhang, Kai]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Haixiang]'s Articles
[McGonigal, Aileen]'s Articles
[Zhang, Kai]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Haixiang]'s Articles
[McGonigal, Aileen]'s Articles
[Zhang, Kai]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.