Institutional Repository of Key Laboratory of Mental Health, CAS
Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder | |
Wang, Kui1,2; Zhao, Yan-li3; Tan, Shu-ping3; Zhang, Jin-guo3; Li, Dong3; Chen, Jing-xu3; Zhang, Li-gang3; Yu, Xin-yang1,2; Zhao, Dan4; Cheung, Eric F. C.5; Turetsky, Bruce I.6; Gur, Ruben C.6; Chan, Raymond C. K.1,2 | |
第一作者 | Wang, Kui |
通讯作者邮箱 | wangk@psych.ac.cn ; rckchan@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Impairment in semantic association has been reported in bipolar disorder (BD) and schizophrenia (SZ) patients and could underlie abnormal speech patterns in both disorders. In this study, we compared the electrophysiological semantic processing features in patients with these two disorders. Participants (n = 61; BD = 19; SZ = 19; healthy controls [HCs] = 23) were administered a semantic judgment task and event-related potentials (ERPs) were recorded. Responses of the two patient groups were significantly slower than HCs, but comparable behavioral semantic priming effects were observed in both patient groups. The N400 priming effect was observed in all groups, with a delayed peak in the two patient groups. The N400 effect was enhanced for both BD and SZ patients over the left frontal and frontal pole region, but SZ patients showed additional reduction of N400 over the right posterior and occipital regions. The N400 mean amplitudes for related targets correlated with less severe negative symptoms in patients with SZ. Discriminant functional analysis using reaction time and N400 measures successfully classified 82% of the participants into their respective clinical groups. These results suggest that patients with BD and SZ have both overlapping and distinctive semantic processing dysfunction. These findings are consistent with the continuum conceptualization of these disorders, but also offer some support for the traditional Kraepelinian dichotomy. |
关键词 | bipolar disorder discriminant analysis event-related potentials (ERPs) N400 schizophrenia semantic priming |
2020-04-01 | |
语种 | 英语 |
DOI | 10.1002/pchj.321 |
发表期刊 | PSYCH JOURNAL |
ISSN | 2046-0252 |
卷号 | 9期号:2页码:247-257 |
期刊论文类型 | article |
收录类别 | SCI |
出版者 | WILEY |
WOS关键词 | ELECTROPHYSIOLOGICAL INSIGHTS ; N400 ABNORMALITIES ; ACTIVATION ; IMPAIRMENT ; ATTENTION ; LANGUAGE ; MANIA ; SCALE |
WOS研究方向 | Psychology |
WOS类目 | Psychology, Multidisciplinary |
WOS记录号 | WOS:000526789700010 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31547 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Kui; Chan, Raymond C. K. |
作者单位 | 1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Beijing Huilongguan Hosp, Beijing, Peoples R China 4.Changchun Normal Univ, Sch Educ, Changchun, Peoples R China 5.Castle Peak Hosp, Hong Kong, Peoples R China 6.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA |
第一作者单位 | 认知与发展心理学研究室 |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Wang, Kui,Zhao, Yan-li,Tan, Shu-ping,et al. Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder[J]. PSYCH JOURNAL,2020,9(2):247-257. |
APA | Wang, Kui.,Zhao, Yan-li.,Tan, Shu-ping.,Zhang, Jin-guo.,Li, Dong.,...&Chan, Raymond C. K..(2020).Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder.PSYCH JOURNAL,9(2),247-257. |
MLA | Wang, Kui,et al."Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder".PSYCH JOURNAL 9.2(2020):247-257. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Semantic processing (632KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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