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Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder
Wang, Kui1,2; Zhao, Yan-li3; Tan, Shu-ping3; Zhang, Jin-guo3; Li, Dong3; Chen, Jing-xu3; Zhang, Li-gang3; Yu, Xin-yang1,2; Zhao, Dan4; Cheung, Eric F. C.5; Turetsky, Bruce I.6; Gur, Ruben C.6; Chan, Raymond C. K.1,2
First AuthorWang, Kui
Correspondent Emailwangk@psych.ac.cn ; rckchan@psych.ac.cn
2020-04-01
Source PublicationPSYCH JOURNAL
ISSN2046-0252
Subtypearticle
Volume9Issue:2Pages:247-257
Contribution Rank1
Abstract

Impairment in semantic association has been reported in bipolar disorder (BD) and schizophrenia (SZ) patients and could underlie abnormal speech patterns in both disorders. In this study, we compared the electrophysiological semantic processing features in patients with these two disorders. Participants (n = 61; BD = 19; SZ = 19; healthy controls [HCs] = 23) were administered a semantic judgment task and event-related potentials (ERPs) were recorded. Responses of the two patient groups were significantly slower than HCs, but comparable behavioral semantic priming effects were observed in both patient groups. The N400 priming effect was observed in all groups, with a delayed peak in the two patient groups. The N400 effect was enhanced for both BD and SZ patients over the left frontal and frontal pole region, but SZ patients showed additional reduction of N400 over the right posterior and occipital regions. The N400 mean amplitudes for related targets correlated with less severe negative symptoms in patients with SZ. Discriminant functional analysis using reaction time and N400 measures successfully classified 82% of the participants into their respective clinical groups. These results suggest that patients with BD and SZ have both overlapping and distinctive semantic processing dysfunction. These findings are consistent with the continuum conceptualization of these disorders, but also offer some support for the traditional Kraepelinian dichotomy.

Keywordbipolar disorder discriminant analysis event-related potentials (ERPs) N400 schizophrenia semantic priming
DOI10.1002/pchj.321
Indexed BySCI
Language英语
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000526789700010
PublisherWILEY
WOS KeywordELECTROPHYSIOLOGICAL INSIGHTS ; N400 ABNORMALITIES ; ACTIVATION ; IMPAIRMENT ; ATTENTION ; LANGUAGE ; MANIA ; SCALE
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31547
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Kui; Chan, Raymond C. K.
Affiliation1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Beijing Huilongguan Hosp, Beijing, Peoples R China
4.Changchun Normal Univ, Sch Educ, Changchun, Peoples R China
5.Castle Peak Hosp, Hong Kong, Peoples R China
6.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
Recommended Citation
GB/T 7714
Wang, Kui,Zhao, Yan-li,Tan, Shu-ping,et al. Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder[J]. PSYCH JOURNAL,2020,9(2):247-257.
APA Wang, Kui.,Zhao, Yan-li.,Tan, Shu-ping.,Zhang, Jin-guo.,Li, Dong.,...&Chan, Raymond C. K..(2020).Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder.PSYCH JOURNAL,9(2),247-257.
MLA Wang, Kui,et al."Semantic processing event-related potential features in patients with schizophrenia and bipolar disorder".PSYCH JOURNAL 9.2(2020):247-257.
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