Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity | |
Cao, Bo1,2; Cho, Raymond Y.3; Chen, Dachun4; Xiu, Meihong4; Wang, Li5; Soares, Jair C.2; Zhang, Xiang Yang5 | |
第一作者 | Cao, Bo |
通讯作者邮箱 | xiang yang zhang zhangxy@psych.ac.cn |
心理所单位排序 | 5 |
摘要 | Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited progress. In this study, by using machine learning algorithms and the functional connections of the superior temporal cortex, we successfully identified the first-episode drug-naive (FEDN) schizophrenia patients (accuracy 78.6%) and predict their responses to antipsychotic treatment (accuracy 82.5%) at an individual level. The functional connections (FC) were derived using the mutual information and the correlations, between the blood-oxygen-level dependent signals of the superior temporal cortex and other cortical regions acquired with the resting-state functional magnetic resonance imaging. We also found that the mutual information and correlation FC was informative in identifying individual FEDN schizophrenia and prediction of treatment response, respectively. The methods and findings in this paper could provide a critical step toward individualized identification and treatment response prediction in first-episode drug-naive schizophrenia, which could complement other biomarkers in the development of precision medicine approaches for this severe mental disorder. |
关键词 | support vector machines SVM |
2020-04-01 | |
语种 | 英语 |
DOI | 10.1038/s41380-018-0106-5 |
发表期刊 | MOLECULAR PSYCHIATRY |
ISSN | 1359-4184 |
卷号 | 25期号:4页码:906-913 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | NARSAD Young Investigator Grant of the Brain & Behavior Research Foundation ; Michael E. Debakey VA Medical Center ; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine in Houston, TX ; NIMH[R01 085667] ; Dunn Research Foundation ; Pat Rutherford, Jr. Endowed Chair in Psychiatry |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | SUPERIOR TEMPORAL GYRUS ; ANTIPSYCHOTIC TREATMENT ; STRUCTURAL MRI ; SEGMENTATION ; PSYCHOSIS ; DISEASE ; PATTERN ; SYSTEM ; MATTER |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry |
WOS记录号 | WOS:000525957300020 |
Q分类 | Q1 |
资助机构 | NARSAD Young Investigator Grant of the Brain & Behavior Research Foundation ; Michael E. Debakey VA Medical Center ; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine in Houston, TX ; NIMH ; Dunn Research Foundation ; Pat Rutherford, Jr. Endowed Chair in Psychiatry |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31556 |
专题 | 健康与遗传心理学研究室 |
通讯作者 | Zhang, Xiang Yang |
作者单位 | 1.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada 2.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100096, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Cao, Bo,Cho, Raymond Y.,Chen, Dachun,et al. Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity[J]. MOLECULAR PSYCHIATRY,2020,25(4):906-913. |
APA | Cao, Bo.,Cho, Raymond Y..,Chen, Dachun.,Xiu, Meihong.,Wang, Li.,...&Zhang, Xiang Yang.(2020).Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity.MOLECULAR PSYCHIATRY,25(4),906-913. |
MLA | Cao, Bo,et al."Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity".MOLECULAR PSYCHIATRY 25.4(2020):906-913. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Treatment response p(792KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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