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Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity
Cao, Bo1,2; Cho, Raymond Y.3; Chen, Dachun4; Xiu, Meihong4; Wang, Li5; Soares, Jair C.2; Zhang, Xiang Yang5
第一作者Cao, Bo
通讯作者邮箱xiang yang zhang zhangxy@psych.ac.cn
心理所单位排序5
摘要

Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited progress. In this study, by using machine learning algorithms and the functional connections of the superior temporal cortex, we successfully identified the first-episode drug-naive (FEDN) schizophrenia patients (accuracy 78.6%) and predict their responses to antipsychotic treatment (accuracy 82.5%) at an individual level. The functional connections (FC) were derived using the mutual information and the correlations, between the blood-oxygen-level dependent signals of the superior temporal cortex and other cortical regions acquired with the resting-state functional magnetic resonance imaging. We also found that the mutual information and correlation FC was informative in identifying individual FEDN schizophrenia and prediction of treatment response, respectively. The methods and findings in this paper could provide a critical step toward individualized identification and treatment response prediction in first-episode drug-naive schizophrenia, which could complement other biomarkers in the development of precision medicine approaches for this severe mental disorder.

关键词support vector machines SVM
2020-04-01
语种英语
DOI10.1038/s41380-018-0106-5
发表期刊MOLECULAR PSYCHIATRY
ISSN1359-4184
卷号25期号:4页码:906-913
期刊论文类型article
收录类别SCI
资助项目NARSAD Young Investigator Grant of the Brain & Behavior Research Foundation ; Michael E. Debakey VA Medical Center ; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine in Houston, TX ; NIMH[R01 085667] ; Dunn Research Foundation ; Pat Rutherford, Jr. Endowed Chair in Psychiatry
出版者NATURE PUBLISHING GROUP
WOS关键词SUPERIOR TEMPORAL GYRUS ; ANTIPSYCHOTIC TREATMENT ; STRUCTURAL MRI ; SEGMENTATION ; PSYCHOSIS ; DISEASE ; PATTERN ; SYSTEM ; MATTER
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS类目Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS记录号WOS:000525957300020
Q分类Q1
资助机构NARSAD Young Investigator Grant of the Brain & Behavior Research Foundation ; Michael E. Debakey VA Medical Center ; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine in Houston, TX ; NIMH ; Dunn Research Foundation ; Pat Rutherford, Jr. Endowed Chair in Psychiatry
引用统计
被引频次:78[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/31556
专题健康与遗传心理学研究室
通讯作者Zhang, Xiang Yang
作者单位1.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada
2.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100096, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
通讯作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Cao, Bo,Cho, Raymond Y.,Chen, Dachun,et al. Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity[J]. MOLECULAR PSYCHIATRY,2020,25(4):906-913.
APA Cao, Bo.,Cho, Raymond Y..,Chen, Dachun.,Xiu, Meihong.,Wang, Li.,...&Zhang, Xiang Yang.(2020).Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity.MOLECULAR PSYCHIATRY,25(4),906-913.
MLA Cao, Bo,et al."Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity".MOLECULAR PSYCHIATRY 25.4(2020):906-913.
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