PSYCH OpenIR  > 中国科学院心理健康重点实验室
The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment
Chen, Yiqi1,2; He, Hao1,2,3,4; Xu, Pengfei1,2,3,4; Wang, Jing1,2; Qiu, Yuehong1,2; Feng, Wei5; Luo, Yuejia1,2,3,4; Hu, Li6; Guan, Qing1,2,3,4
2020-03-12
Source PublicationFRONTIERS IN HUMAN NEUROSCIENCE
ISSN1662-5161
Volume14Pages:10
QuartileQ2
Abstract

Background: Prestimulus alpha oscillations associated with preparatory attention have an impact on response time (RT). However, little is known about whether there is a deficit in the relationship between prestimulus alpha oscillations and RT in older adults with mild cognitive impairment (MCI). Method: We collected electroencephalography (EEG) data from 28 older adults with MCI and 28 demographically matched healthy controls (HCs) when they were performing an Eriksen flanker task. For each participant, single-trial prestimulus alpha power was calculated for combinations of congruency (congruent vs. incongruent) and response speed (fast vs. slow). Result: Statistical analysis indicated that prestimulus alpha power was significantly lower for fast trials than slow trials in HCs but not in older adults with MCI. The Fisher's z scores of the within-subject correlation coefficients between single-trial prestimulus alpha power and RT were significantly larger in HCs than in older adults with MCI. In addition, machine learning analyses indicated that prestimulus alpha power and its correlation with RT could serve as features to distinguish older adults with MCI from HCs and to predict performance on some neuropsychological tests. Conclusion: The reduced correlation between prestimulus alpha activity and RT suggests that older adults with MCI experience impaired preparatory attention.

Keywordmild cognitive impairment preparatory attention prestimulus alpha oscillations response time machine learning
DOI10.3389/fnhum.2020.00048
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions grant ; Shenzhen Science and Technology Research Funding Program ; National Natural Science Foundation of China
Funding ProjectNational Key Research and Development Program of China[2018YFC1315202] ; National Key Research and Development Program of China[2018YFC1315205] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions grant[2019SHIBS0003] ; Shenzhen Science and Technology Research Funding Program[JCYJ20180507183500566] ; National Natural Science Foundation of China[31700960]
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000525489300001
PublisherFRONTIERS MEDIA SA
WOS KeywordTOP-DOWN MODULATION ; PRE-STIMULUS ALPHA ; ALZHEIMERS-DISEASE ; PREPARATORY ATTENTION ; EEG ; BRAIN ; PERFORMANCE ; INHIBITION ; DEMENTIA ; PREDICT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31559
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, Li; Guan, Qing
Affiliation1.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, Shenzhen, Peoples R China
2.Shenzhen Univ, Sch Psychol, Shenzhen, Peoples R China
3.Shenzhen Fundamental Res Inst, Shenzhen Hong Kong Inst Brain Sci, Shenzhen, Peoples R China
4.Shenzhen Inst Neurosci, Ctr Neuroimaging, Shenzhen, Peoples R China
5.Jilin Med Univ, Sch Marxism, Jilin, Jilin, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chen, Yiqi,He, Hao,Xu, Pengfei,et al. The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2020,14:10.
APA Chen, Yiqi.,He, Hao.,Xu, Pengfei.,Wang, Jing.,Qiu, Yuehong.,...&Guan, Qing.(2020).The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment.FRONTIERS IN HUMAN NEUROSCIENCE,14,10.
MLA Chen, Yiqi,et al."The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment".FRONTIERS IN HUMAN NEUROSCIENCE 14(2020):10.
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