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Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography
Wang, Yong-ming1,2,3,4; Yang, Zhuo-ya1,4; Cai, Xin-lu1,2,3,4; Zhou, Han-yu1,4; Zhang, Rui-ting1,4; Yang, Han-xue1,4; Liang, Yun-si1,2,3,4; Zhu, Xiong-zhao5,6; Madsen, Kristoffer Hougaard3,7,8; Sorensen, Thomas Alrik3,9; Moller, Arne3,10,11; Wang, Zhen12; Cheung, Eric F. C.13; Chan, Raymond C. K.1,2,3,4
Corresponding AuthorChan, Raymond C. K.(rckchan@psych.ac.cn)
2020-03-01
Source PublicationSCHIZOPHRENIA BULLETIN
ISSN0586-7614
Volume46Issue:2Pages:442-453
AbstractA phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.
Keyworddiffusion tensor imaging schizo-obsessive comorbidity schizophrenia obsessive-compulsive disorder support vector classification
DOI10.1093/schbul/sbz073
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in S T ; Strategic Priority Research Programme (B) of the Chinese Academy of Science ; CAS Key Laboratory of Mental Health, Institute of Psychology
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Strategic Priority Research Programme (B) of the Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000525861400027
PublisherOXFORD UNIV PRESS
WOS KeywordCOMPULSIVE DISORDER OCD ; NEUROLOGICAL SOFT SIGNS ; WHITE-MATTER INTEGRITY ; FREE-WATER ELIMINATION ; SCHIZOPHRENIA PREVALENCE ; COGNITIVE DEFICITS ; BED NUCLEUS ; BDNF GENE ; HIGH-RISK ; CONNECTIVITY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31562
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Cent South Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha, Hunan, Peoples R China
6.Cent South Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China
7.Copenhagen Univ Hosp Hvidovre, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, Copenhagen, Denmark
8.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
9.Aalborg Univ, Ctr Cognit Neurosci, Dept Commun & Psychol, Aalborg, Denmark
10.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
11.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
12.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
13.Castle Peak Hosp, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yong-ming,Yang, Zhuo-ya,Cai, Xin-lu,et al. Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography[J]. SCHIZOPHRENIA BULLETIN,2020,46(2):442-453.
APA Wang, Yong-ming.,Yang, Zhuo-ya.,Cai, Xin-lu.,Zhou, Han-yu.,Zhang, Rui-ting.,...&Chan, Raymond C. K..(2020).Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography.SCHIZOPHRENIA BULLETIN,46(2),442-453.
MLA Wang, Yong-ming,et al."Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography".SCHIZOPHRENIA BULLETIN 46.2(2020):442-453.
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