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Smoking cues impair monitoring but not stopping during response inhibition in abstinent male smokers
Zhao, Haichao1,2; Turel, Ofir3,4,5; Brevers, Damien6; Bechara, Antoine3,4; He, Qinghua1,7,8,9
First AuthorZhao, Haichao
Correspondent Emailheqinghua@swu.edu.cn (q. he)
2020-05-27
Source PublicationBEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
Subtypearticle
Volume386Pages:9
Abstract

The attenuated inhibitory control of smokers is a stumbling block for treating nicotine dependence. Unfortunately, smokers are often exposed to cigarette-related salient cues, which may violate homeostasis, override self-control, and lead to relapse. To understand the mechanisms underlying these associations, we investigate the cognitive and neural processes of inhibitory control (including proactive and reactive inhibition) of smoking cues in abstinent smokers. Twenty-six smokers completed cue-reactivity and stop signal tasks during functional magnetic resonance imaging scans, on two separate sessions, 2-3 weeks apart one involved a neutral cue reactivity task, and the other a smoking cue reactivity task. Findings pointed to no significant subjective craving changes, or behavioral influences of smoking cues on proactive and reactive inhibition. However, abstinent smokers exhibited hyperactive brain reactivity in response to smoking versus neutral stimuli, in regions including the insula, amygdala, anterior cingulate cortex (ACC), and putamen. They also had hypoactive bilateral rostral ACC (rACC) and hyperactive right pre-supplementary motor area during reactive inhibition in smoking versus neutral conditions. Support vector regression analysis showed that activation of these regions predicted and correlated with reactive inhibition index (i.e., SSRT), alluding to the possibility of their involvement in the reactive inhibition. Subjective craving scores were predicted by and correlated with activation of bilateral dorsal and rostral ACC, supporting the ideas of their possible involvement in subjective craving. These findings suggest that smoking cues evoke hyperactive brain reactivity; this may interfere with normal performance monitoring and rapid reactive inhibition. These findings have important implication for treating smoking dependence.

KeywordSmoking cue Response inhibition ACC pre-SM Abstinent smoker
DOI10.1016/j.bbr.2020.112605
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; High-end Foreign Expert Introduction Program
Funding ProjectNational Natural Science Foundation of China[31972906] ; Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars[cx2017049] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences[KLMH2019K05] ; High-end Foreign Expert Introduction Program[G20190022029]
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000526072600015
PublisherELSEVIER
WOS KeywordANTERIOR CINGULATE CORTEX ; ATTENTIONAL BIAS ; FRONTAL-CORTEX ; IMPULSIVE BEHAVIOR ; PREFRONTAL CORTEX ; ALCOHOL CUES ; SELF-REPORT ; TIME-COURSE ; MOTOR AREA ; SIGNAL
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31565
Collection中国科学院心理健康重点实验室
Corresponding AuthorHe, Qinghua
Affiliation1.Southwest Univ, Fac Psychol, 2 Tiansheng Rd, Chongqing 400715, Peoples R China
2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing, Peoples R China
3.Univ Southern Calif, Dept Psychol, Los Angeles, CA 90007 USA
4.Univ Southern Calif, Brain & Creat Inst, Los Angeles, CA 90007 USA
5.Calif State Univ Fullerton, Dept Informat Syst & Decis Sci, Fullerton, CA 92634 USA
6.Univ Luxembourg, Addict & Compuls Behav Lab ACB Lab, Dept Behav & Cognit Sci, Campus Belval, Esch Sur Alzette, Luxembourg
7.Chongqing Collaborat Innovat Ctr Brain Sci, Chongqing, Peoples R China
8.Beijing Normal Univ, Southwest Univ Branch, Collaborat Innovat Ctr Assessment Basic Educ Qual, Chongqing, Peoples R China
9.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhao, Haichao,Turel, Ofir,Brevers, Damien,et al. Smoking cues impair monitoring but not stopping during response inhibition in abstinent male smokers[J]. BEHAVIOURAL BRAIN RESEARCH,2020,386:9.
APA Zhao, Haichao,Turel, Ofir,Brevers, Damien,Bechara, Antoine,&He, Qinghua.(2020).Smoking cues impair monitoring but not stopping during response inhibition in abstinent male smokers.BEHAVIOURAL BRAIN RESEARCH,386,9.
MLA Zhao, Haichao,et al."Smoking cues impair monitoring but not stopping during response inhibition in abstinent male smokers".BEHAVIOURAL BRAIN RESEARCH 386(2020):9.
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