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Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia
Kong, Li1,2; Herold, Christina J.3; Cheung, Eric F. C.4; Chan, Raymond C. K.2,5; Schroeder, Johannes3
第一作者Kong, Li
通讯作者邮箱rckchan@psych.ac.cn
心理所单位排序2
摘要

Neurological soft signs (NSS) are often found in patients with schizophrenia. A wealth of neuroimaging studies have reported that NSS are related to disturbed cortical-subcortical-cerebellar circuitry in schizophrenia. However, the association between NSS and brain network abnormalities in patients with schizophrenia remains unclear. In this study, the graph theoretical approach was used to analyze brain network characteristics based on structural magnetic resonance imaging (MRI) data. NSS were assessed using the Heidelberg scale. We found that there was no significant difference in global network properties between individuals with high and low levels of NSS. Regional network analysis showed that NSS were associated with betweenness centrality involving the inferior orbital frontal cortex, the middle temporal cortex, the hippocampus, the supramarginal cortex, the amygdala, and the cerebellum. Global network analysis also demonstrated that NSS were associated with the distribution of network hubs involving the superior medial frontal cortex, the superior and middle temporal cortices, the postcentral cortex, the amygdala, and the cerebellum. Our findings suggest that NSS are associated with alterations in topological attributes of brain networks corresponding to the cortical-subcortical-cerebellum circuit in patients with schizophrenia, which may provide a new perspective for elucidating the neural basis of NSS in schizophrenia.

关键词neurological soft signs gray matter structural brain network schizophrenia graph theoretical approach network characteristics
2020-05-01
语种英语
DOI10.1093/schbul/sbz118
发表期刊SCHIZOPHRENIA BULLETIN
ISSN0586-7614
卷号46期号:3页码:562-571
期刊论文类型article
收录类别SCI
资助项目National Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China[81601170]
出版者OXFORD UNIV PRESS
WOS关键词GRAPH-THEORETICAL ANALYSIS ; SMALL-WORLD ; SENSORIMOTOR CORTEX ; CORTICAL THICKNESS ; ORGANIZATION ; DYSFUNCTION ; MORPHOLOGY ; PSYCHOSIS ; CONNECTIVITY ; GYRIFICATION
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000525862800014
Q分类Q1
资助机构National Key Research and Development Programme ; Beijing Training Project for the Leading Talents in Science and Technology ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/31568
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Shanghai Normal Univ, Coll Educ, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Heidelberg Univ, Dept Psychiat, Sect Geriatr Psychiat, Heidelberg, Germany
4.Castle Peak Hosp, Dept Adult Psychiat, Hong Kong, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
第一作者单位认知与发展心理学研究室
通讯作者单位认知与发展心理学研究室
推荐引用方式
GB/T 7714
Kong, Li,Herold, Christina J.,Cheung, Eric F. C.,et al. Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2020,46(3):562-571.
APA Kong, Li,Herold, Christina J.,Cheung, Eric F. C.,Chan, Raymond C. K.,&Schroeder, Johannes.(2020).Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia.SCHIZOPHRENIA BULLETIN,46(3),562-571.
MLA Kong, Li,et al."Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia".SCHIZOPHRENIA BULLETIN 46.3(2020):562-571.
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