PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia
Kong, Li1,2; Herold, Christina J.3; Cheung, Eric F. C.4; Chan, Raymond C. K.2,5; Schroeder, Johannes3
First AuthorKong, Li
Correspondent Emailrckchan@psych.ac.cn
2020-05-01
Source PublicationSCHIZOPHRENIA BULLETIN
ISSN0586-7614
Subtypearticle
Volume46Issue:3Pages:562-571
QuartileQ1
Contribution Rank2
Abstract

Neurological soft signs (NSS) are often found in patients with schizophrenia. A wealth of neuroimaging studies have reported that NSS are related to disturbed cortical-subcortical-cerebellar circuitry in schizophrenia. However, the association between NSS and brain network abnormalities in patients with schizophrenia remains unclear. In this study, the graph theoretical approach was used to analyze brain network characteristics based on structural magnetic resonance imaging (MRI) data. NSS were assessed using the Heidelberg scale. We found that there was no significant difference in global network properties between individuals with high and low levels of NSS. Regional network analysis showed that NSS were associated with betweenness centrality involving the inferior orbital frontal cortex, the middle temporal cortex, the hippocampus, the supramarginal cortex, the amygdala, and the cerebellum. Global network analysis also demonstrated that NSS were associated with the distribution of network hubs involving the superior medial frontal cortex, the superior and middle temporal cortices, the postcentral cortex, the amygdala, and the cerebellum. Our findings suggest that NSS are associated with alterations in topological attributes of brain networks corresponding to the cortical-subcortical-cerebellum circuit in patients with schizophrenia, which may provide a new perspective for elucidating the neural basis of NSS in schizophrenia.

Keywordneurological soft signs gray matter structural brain network schizophrenia graph theoretical approach network characteristics
DOI10.1093/schbul/sbz118
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Programme ; Beijing Training Project for the Leading Talents in Science and Technology ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China[81601170]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000525862800014
PublisherOXFORD UNIV PRESS
WOS KeywordGRAPH-THEORETICAL ANALYSIS ; SMALL-WORLD ; SENSORIMOTOR CORTEX ; CORTICAL THICKNESS ; ORGANIZATION ; DYSFUNCTION ; MORPHOLOGY ; PSYCHOSIS ; CONNECTIVITY ; GYRIFICATION
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31568
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Shanghai Normal Univ, Coll Educ, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Heidelberg Univ, Dept Psychiat, Sect Geriatr Psychiat, Heidelberg, Germany
4.Castle Peak Hosp, Dept Adult Psychiat, Hong Kong, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Kong, Li,Herold, Christina J.,Cheung, Eric F. C.,et al. Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2020,46(3):562-571.
APA Kong, Li,Herold, Christina J.,Cheung, Eric F. C.,Chan, Raymond C. K.,&Schroeder, Johannes.(2020).Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia.SCHIZOPHRENIA BULLETIN,46(3),562-571.
MLA Kong, Li,et al."Neurological Soft Signs and Brain Network Abnormalities in Schizophrenia".SCHIZOPHRENIA BULLETIN 46.3(2020):562-571.
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