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Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline
Zhang, Yu1,2,3; Xu, Hang1; Wang, Jiesi1; Ren, Fengyan1,2; Shao, Feng4; Ellenbroek, Bart5; Lin, Wenjuan1,2; Wang, Weiwen1,2
Corresponding AuthorWang, Weiwen(wangww@psych.ac.cn)
2019-11-18
Source PublicationBEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
Volume374Pages:7
AbstractIncreasing evidence shows that the developmental perturbation of immune activity can lead to long-lasting neurodevelopmental and behavioral abnormalities. In our previous study, we found that deficiencies of microglia and TNF alpha in the medial prefrontal cortex (mPFC) were involved in the impairment of cognitive flexibility induced by adolescent social stress in adult mice. It remains unclear how and when immune changes occur following adolescent stress exposure and whether it is possible to prevent the delayed occurrence of cognitive impairment through early immune intervention. Firstly, the present study investigated the time courses of microglia and TNF alpha changes in the mPFC following adolescent social stress. The results showed that compared to the controls, stress-exposed animals showed parallel variations in the protein expression of ionized calciumbinding adaptor molecule 1 (Iba1), a biomarker specific to microglia, and TNF alpha in the mPFC, with a transient increase during stress exposure, then a gradual decrease after the end of stress, leading to a significantly decreased level in adulthood. We further investigated the preventive effect of chronic treatment with the immune inhibitor minocycline during stress exposure on the cognitive and molecular alterations induced by adolescent social stress. The results showed that minocycline prevented the delayed cognitive deficit and the decreased immune changes in the mPFC of previously stressed adult mice. These results suggest that the transient upregulation of microglia and TNF alpha in the mPFC induced by adolescent social stress may participate in the development of cognitive flexibility deficit and that immunomodulation may act as a potential target for the early prevention of cognitive deficits in psychiatric disorders.
KeywordAdolescent social stress Medial prefrontal cortex (mPFC) Microglia Tumor necrosis factor alpha (TNF alpha) Cognitive flexibility
DOI10.1016/j.bbr.2019.112136
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; CAS Key Laboratory of Mental Health, Institute of Psychology
Funding ProjectNational Natural Science Foundation of China[31771217] ; National Natural Science Foundation of China[81471122] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000526053900024
PublisherELSEVIER
WOS KeywordEARLY-LIFE STRESS ; MEDIAL PREFRONTAL CORTEX ; DEFEAT STRESS ; MICROGLIA ; BRAIN ; DEPRESSION ; BEHAVIOR ; HIPPOCAMPUS ; DYSFUNCTION
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31590
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Weiwen
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China
4.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing, Peoples R China
5.Victoria Univ Wellington, Sch Psychol, Wellington 6012, New Zealand
Recommended Citation
GB/T 7714
Zhang, Yu,Xu, Hang,Wang, Jiesi,et al. Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline[J]. BEHAVIOURAL BRAIN RESEARCH,2019,374:7.
APA Zhang, Yu.,Xu, Hang.,Wang, Jiesi.,Ren, Fengyan.,Shao, Feng.,...&Wang, Weiwen.(2019).Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline.BEHAVIOURAL BRAIN RESEARCH,374,7.
MLA Zhang, Yu,et al."Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline".BEHAVIOURAL BRAIN RESEARCH 374(2019):7.
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