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Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence
Li, Rui1,2; Zhang, Jing3; Wu, Xia4; Wen, Xiaotong3; Han, Buxin1,2
First AuthorLi, Rui ; Zhang, Jing
Correspondent Emaillir@psych.ac.cn
2020-04-24
Source PublicationBRAIN STRUCTURE & FUNCTION
ISSN1863-2653
SubtypeSCI
Pages14
QuartileQ1
Contribution Rank1
Abstract

The connectivity hub property of the hippocampus (HIP) and the medial prefrontal cortex (MPFC) is essential for their widespread involvement in cognition; however, the cooperation mechanism between them is far from clear. Herein, using resting-state functional MRI and Gaussian Bayesian network to describe the directed organizing architecture of the HIP-MPFC pathway with regions in the brain, we demonstrated that the HIP and the MPFC have central roles as the driving hub and aggregating hub, respectively. The status of the HIP and the MPFC is dominant in communications between the HIP and the default-mode network, between the HIP and core neurocognitive networks, including the default-mode, frontoparietal, and salience networks, and between brain-wide representative regions, suggesting a strong and robust central position of the two regions in regulating the dynamics of large-scale brain activity. Furthermore, we found that the directed connectivity and flow from the right HIP to the MPFC is significantly linked to fluid intelligence. Together, these results clarify the different roles of the HIP and the MPFC that jointly contribute to network dynamics and cognitive ability from a data-driven insight via the use of the directed connectivity method.

KeywordConnectivity Hippocampus Intelligence Medial prefrontal Resting state
DOI10.1007/s00429-020-02077-8
Indexed BySCI
Language英语
Funding Organizationfund for building world-class universities (disciplines) of Renmin University of China
Funding Projectfund for building world-class universities (disciplines) of Renmin University of China[2018]
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000528517800001
PublisherSPRINGER HEIDELBERG
WOS KeywordINDEPENDENT COMPONENT ANALYSIS ; FUNCTIONAL CONNECTIVITY ; DEFAULT MODE ; NEURAL MECHANISMS ; NETWORK ; MEMORY ; ORGANIZATION ; MRI ; REGISTRATION ; OSCILLATIONS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31705
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Rui
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Renmin Univ China, Dept Psychol, Beijing, Peoples R China
4.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Rui,Zhang, Jing,Wu, Xia,et al. Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence[J]. BRAIN STRUCTURE & FUNCTION,2020:14.
APA Li, Rui,Zhang, Jing,Wu, Xia,Wen, Xiaotong,&Han, Buxin.(2020).Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence.BRAIN STRUCTURE & FUNCTION,14.
MLA Li, Rui,et al."Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence".BRAIN STRUCTURE & FUNCTION (2020):14.
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