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The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations
Yue, Lupeng1,2; Iannetti, G. D.3,4; Hu, Li1,2
First AuthorLupeng Yue
Correspondent Emailhuli@psych.ac.cn.
2020-04-22
Source PublicationJOURNAL OF NEUROSCIENCE
ISSN0270-6474
Subtypearticle
Volume40Issue:17Pages:3478-3490
QuartileQ1
Contribution Rank1
Abstract

Gamma-band oscillations (GBOs) elicited by transient nociceptive stimuli are one of the most promising biomarkers of pain across species. Still, whether these GBOs reflect stimulus encoding in the primary somatosensory cortex (Si) or nocifensive behavior in the primary motor cortex (Ml) is debated. Here we recorded neural activity simultaneously from the brain surface as well as at different depths of the bilateral Sl/MI in freely-moving male rats receiving nociceptive stimulation. GBOs measured from superficial layers of Si contralateral to the stimulated paw not only had the largest magnitude, but also showed the strongest temporal and phase coupling with epidural GBOs. Also, spiking of superficial SI interneurons had the strongest phase coherence with epidural GBOs. These results provide the first direct demonstration that scalp GBOs, one of the most promising pain biomarkers, reflect neural activity strongly coupled with the fast spiking of interneurons in the superficial layers of the Si contralateral to the stimulated side.

Keywordbiomarkers gamma-band oscillations interneurons pain primary motor cortex primary somatosensory cortex
DOI10.1523/JNEUROSCI.0255-20.2020
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences ; European Research Council (ERC Consolidator Grant PAINSTRAT) ; Wellcome Trust (COLL JLARAXR)
Funding ProjectNational Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31671141] ; Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; European Research Council (ERC Consolidator Grant PAINSTRAT) ; Wellcome Trust (COLL JLARAXR)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000528267300012
PublisherSOC NEUROSCIENCE
WOS KeywordPRIMARY SOMATOSENSORY CORTEX ; PYRAMIDAL NEURONS ; PAIN MATRIX ; RESPONSES ; REFLECT ; EEG ; CONNECTIVITY ; ISSUES ; SYNCHRONIZATION ; POTENTIALS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31711
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, Li
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Ist Italiano Tecnol, Neurosci & Behav Lab, I-00161 Rome, Italy
4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
Recommended Citation
GB/T 7714
Yue, Lupeng,Iannetti, G. D.,Hu, Li. The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations[J]. JOURNAL OF NEUROSCIENCE,2020,40(17):3478-3490.
APA Yue, Lupeng,Iannetti, G. D.,&Hu, Li.(2020).The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations.JOURNAL OF NEUROSCIENCE,40(17),3478-3490.
MLA Yue, Lupeng,et al."The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations".JOURNAL OF NEUROSCIENCE 40.17(2020):3478-3490.
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