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The clock-controlled chemokine contributes to neuroinflammation-induced depression
Chen, Xiaojuan1,2; Hu, Qianying1,2; Zhang, Ke1,2; Teng, Huajing3; Li, Mingzhen1; Li, Dan1,2; Wang, Jiesi1,2; Du, Quansheng4; Zhao, Mei1,2
First AuthorChen, Xiaojuan
Correspondent Emailzhaomei@psych.ac.cn
2020-04-23
Source PublicationFASEB JOURNAL
ISSN0892-6638
Subtypearticle
Pages10
QuartileQ1
Contribution Rank1
Abstract

The circadian rhythm plays a central role in immune function, and its disruption has been closely linked to the etiology of depression. However, the mechanisms underlying the association between depression and circadian rhythm remain unclear. We found that mice deficient of Per2, a central clock component of circadian output, were resilient to neuroinflammation-induced depressive behavior. After repeated central lipopolysaccharide (LPS) injections, MCP-1, MIP-1 beta, and RANTES increased in wild type (WT) but not in Per2-deficient mice. In addition, intracerebroventricular injection of RANTES resulted in depression-like behavior, and Met-RANTES, a CCR5 antagonist, could reverse depression-like behavior induced by LPS treatments. These results indicated that the Per2 gene contributes to depression via chemokines, especially RANTES. Furthermore, BMAL1 expression decreased in LPS-treated Per2-deficient mice and BMAL1 could bind to the promoter of Rantes, indicating clock gene can act as a regulator for neuroinflammation. In conclusion, Rantes, a clock-controlled gene (CCG), is involved in clock-immunological mechanisms underlying the effects of Per2 on neuroinflammation-induced depression-like behavior.

Keywordclock gene cytokine depression-like behavior inflammation Per2
DOI10.1096/fj.201900581RRR
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Funding ProjectNational Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[31741062] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biology ; Cell Biology
WOS IDWOS:000529406900001
PublisherWILEY
WOS KeywordCIRCADIAN-CLOCK ; GENE ; ABNORMALITIES ; IMMUNOLOGY ; EXPRESSION ; MICROGLIA ; ANXIETY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31724
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhao, Mei
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China
4.Natl Nat Sci Fdn China, Dept Life Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xiaojuan,Hu, Qianying,Zhang, Ke,et al. The clock-controlled chemokine contributes to neuroinflammation-induced depression[J]. FASEB JOURNAL,2020:10.
APA Chen, Xiaojuan.,Hu, Qianying.,Zhang, Ke.,Teng, Huajing.,Li, Mingzhen.,...&Zhao, Mei.(2020).The clock-controlled chemokine contributes to neuroinflammation-induced depression.FASEB JOURNAL,10.
MLA Chen, Xiaojuan,et al."The clock-controlled chemokine contributes to neuroinflammation-induced depression".FASEB JOURNAL (2020):10.
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