PSYCH OpenIR  > 健康与遗传心理学研究室
One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia
Xia, Luyao1,2; Liu, Lei3; Hong, Xiaohong3; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Tian, Yang1,2; Dai, Qilong1,2; Wu, Hanjing E.4; Chang, Catherine4; Wang, Li1,2; Kosten, Thomas R.5; Zhang, Xiang Yang1,2
第一作者Luyao Xia
通讯作者邮箱xiang yang zhang (zhangxy@psych.ac.cn)
心理所单位排序1
摘要

The core features of schizophrenia (SCZ) include cognitive deficits and impaired sensory gating represented by P50 inhibition deficits, which appear to be related to the alpha 7 nicotinic acetylcholine receptor (nAChR). An agonist of nAChR receptor may improve these defects. This study aimed to investigate how administering multiple doses of tropisetron, a partial agonist of nAChR, for 1 day would affect cognitive deficits and P50 inhibition deficits in SCZ patients. We randomized 40 SCZ non-smokers into a double-blind clinical trial with four groups: placebo, 5 mg/d, 10 mg/d, and 20 mg/d of oral tropisetron. Their P50 ratios were all more than 0.5 and they took risperidone at 3-6 mg/day for at least a month before participating in the experiment. We measured the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and P50 inhibition before and one day after treatment. After one day of treatment, the total RBANS scores of the 20 mg and 5 mg tropisetron groups, and the immediate memory of the 10 mg group were significantly higher than placebo group. The P50 ratio was smaller in the 5 mg and 10 mg groups than in the placebo group (both p < 0.05) after treatment. Furthermore, the improvement in RBANS total score was correlated with increased S1 latency (p < 0.05), and the increase in immediate memory score was correlated with decreased S2 amplitude. One day of treatment with tropisetron improved both cognitive and P50 inhibition deficits, suggesting that longer term treatment with alpha 7 nAChR agonists for these deficits in SCZ may be promising.

2020-04-29
语种英语
DOI10.1038/s41386-020-0685-0
发表期刊NEUROPSYCHOPHARMACOLOGY
ISSN0893-133X
卷号45期号:8页码:1362-1368
收录类别SCI
资助项目National Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program
出版者NATURE PUBLISHING GROUP
WOS关键词NICOTINIC ACETYLCHOLINE-RECEPTOR ; NEUROPSYCHOLOGICAL STATUS ; REPEATABLE BATTERY ; SMOKING INITIATION ; CIGARETTE-SMOKING ; AGONIST ; RISPERIDONE ; TARGET ; METAANALYSIS ; ASSOCIATION
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000530248000002
WOS分区Q1
Q分类Q1
资助机构National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/31727
专题健康与遗传心理学研究室
通讯作者Zhang, Xiang Yang
作者单位1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Shantou Univ, Mental Hlth Ctr, Shantou, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
第一作者单位中国科学院心理研究所
通讯作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Xia, Luyao,Liu, Lei,Hong, Xiaohong,et al. One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia[J]. NEUROPSYCHOPHARMACOLOGY,2020,45(8):1362-1368.
APA Xia, Luyao.,Liu, Lei.,Hong, Xiaohong.,Wang, Dongmei.,Wei, Gaoxia.,...&Zhang, Xiang Yang.(2020).One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia.NEUROPSYCHOPHARMACOLOGY,45(8),1362-1368.
MLA Xia, Luyao,et al."One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia".NEUROPSYCHOPHARMACOLOGY 45.8(2020):1362-1368.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
One-day tropisetron (507KB)期刊论文出版稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xia, Luyao]的文章
[Liu, Lei]的文章
[Hong, Xiaohong]的文章
百度学术
百度学术中相似的文章
[Xia, Luyao]的文章
[Liu, Lei]的文章
[Hong, Xiaohong]的文章
必应学术
必应学术中相似的文章
[Xia, Luyao]的文章
[Liu, Lei]的文章
[Hong, Xiaohong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。