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One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia
Xia, Luyao1,2; Liu, Lei3; Hong, Xiaohong3; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Tian, Yang1,2; Dai, Qilong1,2; Wu, Hanjing E.4; Chang, Catherine4; Wang, Li1,2; Kosten, Thomas R.5; Zhang, Xiang Yang1,2
First AuthorLuyao Xia
Correspondent Emailxiang yang zhang (zhangxy@psych.ac.cn)
2020-04-29
Source PublicationNEUROPSYCHOPHARMACOLOGY
ISSN0893-133X
Subtypearticle
Pages7
QuartileQ1
Contribution Rank1
Abstract

The core features of schizophrenia (SCZ) include cognitive deficits and impaired sensory gating represented by P50 inhibition deficits, which appear to be related to the alpha 7 nicotinic acetylcholine receptor (nAChR). An agonist of nAChR receptor may improve these defects. This study aimed to investigate how administering multiple doses of tropisetron, a partial agonist of nAChR, for 1 day would affect cognitive deficits and P50 inhibition deficits in SCZ patients. We randomized 40 SCZ non-smokers into a double-blind clinical trial with four groups: placebo, 5 mg/d, 10 mg/d, and 20 mg/d of oral tropisetron. Their P50 ratios were all more than 0.5 and they took risperidone at 3-6 mg/day for at least a month before participating in the experiment. We measured the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and P50 inhibition before and one day after treatment. After one day of treatment, the total RBANS scores of the 20 mg and 5 mg tropisetron groups, and the immediate memory of the 10 mg group were significantly higher than placebo group. The P50 ratio was smaller in the 5 mg and 10 mg groups than in the placebo group (both p < 0.05) after treatment. Furthermore, the improvement in RBANS total score was correlated with increased S1 latency (p < 0.05), and the increase in immediate memory score was correlated with decreased S2 amplitude. One day of treatment with tropisetron improved both cognitive and P50 inhibition deficits, suggesting that longer term treatment with alpha 7 nAChR agonists for these deficits in SCZ may be promising.

DOI10.1038/s41386-020-0685-0
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program
Funding ProjectNational Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000530248000002
PublisherNATURE PUBLISHING GROUP
WOS KeywordNICOTINIC ACETYLCHOLINE-RECEPTOR ; NEUROPSYCHOLOGICAL STATUS ; REPEATABLE BATTERY ; SMOKING INITIATION ; CIGARETTE-SMOKING ; AGONIST ; RISPERIDONE ; TARGET ; METAANALYSIS ; ASSOCIATION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31727
Collection健康与遗传心理学研究室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Shantou Univ, Mental Hlth Ctr, Shantou, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xia, Luyao,Liu, Lei,Hong, Xiaohong,et al. One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia[J]. NEUROPSYCHOPHARMACOLOGY,2020:7.
APA Xia, Luyao.,Liu, Lei.,Hong, Xiaohong.,Wang, Dongmei.,Wei, Gaoxia.,...&Zhang, Xiang Yang.(2020).One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia.NEUROPSYCHOPHARMACOLOGY,7.
MLA Xia, Luyao,et al."One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia".NEUROPSYCHOPHARMACOLOGY (2020):7.
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