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Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus
Zhang, Chun-Jing1; Guo, Jian-You2; Cheng, Hao3; Li, Lin4; Liu, Ying1; Shi, Yan1; Xu, Jing1; Yu, Hai-Tao5
First AuthorZhang, Chun-Jing
Correspondent Emailyht422@126.com (h.-t. yu)
2020-05-15
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
SubtypeArticle
Volume151Pages:855-860
QuartileQ1
Contribution Rank2
Abstract

The aim of this study was to evaluate the spatial structure and potential antifatigue activity of polysaccharide fractions which was extracted from Inonotus obliquus. The first polysaccharide fractions of Inonotus obliquus (PIO-1) were obtained after hot-water extraction and purification by DEAE cellulose-52 chromatography. Results of the forced swimming test showed that the doses (50 mg/kg) of PIO-1 could increase the climbing duration and swimming time as well as reduced the immobility time in the PIO treated mice. The fatigue related metabolic parameters showed that PIO-1 decreased the level of blood lactic acid (BLA), urea nitrogen (BUN) and lactic dehydrogenase (LDH). Additionally, PIO-1 significantly decreased the 5-HT concentrations in the mice brain. The results of monosaccharide analysis showed that the molar ratio of mannose, glucose, galactose, xylose and arabinose with the molar ratio of 1.0:1.9:3.5:18.5:5.7. The molecular morphology of the PIO-1 observed under atomic force microscopy (AFM). There were many spherical and heterogeneous clumps existed in the images. Therefore. current study indicated polysaccharide PIO-1 not only has great potential to postpone physical fatigue but also shown potential to improve mental fatigue. (C) 2020 Elsevier B.V. All rights reserved.

KeywordInonotus obliquus Polysaccharide Physical fatigue Mental fatigue
DOI10.1016/j.ijbiomac.2020.02.147
Indexed BySCI
Language英语
Funding OrganizationPostdoctoral Researcher of Heilongjiang Postdoctoral Management Office ; Qiqihar Medical University
Funding ProjectPostdoctoral Researcher of Heilongjiang Postdoctoral Management Office[LBH-Q16225] ; Postdoctoral Researcher of Heilongjiang Postdoctoral Management Office[LBH-Q17177] ; Qiqihar Medical University[QY2016LX-01]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000528267400086
PublisherELSEVIER
WOS KeywordENDO-POLYSACCHARIDE ; SUBMERGED CULTURE ; PERFORMANCE ; EXERCISE ; EXTRACT ; ACID
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31739
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Hai-Tao
Affiliation1.Qiqihar Med Univ, Dept Biochem, Qiqihar 161006, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Qiqihar Med Univ, Affiliated Hosp 3, Qiqihar 161006, Heilongjiang, Peoples R China
4.Qiqihar Med Univ, Dept Clin Biochem, Qiqihar 161006, Heilongjiang, Peoples R China
5.Qiqihar Med Univ, Dept Biol Genet, Qiqihar 161006, Heilongjiang, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Chun-Jing,Guo, Jian-You,Cheng, Hao,et al. Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,151:855-860.
APA Zhang, Chun-Jing.,Guo, Jian-You.,Cheng, Hao.,Li, Lin.,Liu, Ying.,...&Yu, Hai-Tao.(2020).Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,151,855-860.
MLA Zhang, Chun-Jing,et al."Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 151(2020):855-860.
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