Institutional Repository of Key Laboratory of Mental Health, CAS
Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors | |
Shen, Yanmei1,2; Wei, Ying3; Yang, Xu-Na4; Zhang, Guangya4; Du, Xiangdong4; Jia, Qiufang4; Zhu, Xiaomin4; Ma, Yuejiao1,2; Lang, XiaoE5; Luo, Xuerong1,2; Zhang, Xiang Yang6,7 | |
第一作者 | Shen, Yanmei |
通讯作者邮箱 | luoxuerong@csu.edu.cn ; zhangxy@psych.ac.cn |
心理所单位排序 | 6 |
摘要 | Background Many patients with major depressive disorder (MDD) have been found to have psychotic symptoms. However, few studies have reported the prevalence of comorbid psychotic symptoms in first-episode drug naive (FEDN) MDD patients. This study was to investigate the prevalence of psychotic symptoms and related risk factors in a large sample size of FEDN MDD patients in a Chinese population. Methods A total of 573 patients with diagnosis of MDD at their first episode were recruited with their demographic and clinical data. Positive scale of the Positive and Negative Syndrome Scale was utilized for psychotic symptoms, Hamilton Anxiety Rating Scale (HAMA) for anxiety symptoms, and Hamilton Depression Rating Scale (HAMD) for depressive symptoms. Results The prevalence of psychotic symptoms in these MDD patients was 9.8%. MDD patients with psychotic symptoms had significantly higher HAMD and HAMA total scores than those without psychotic symptoms (both p < .001). A strong association was found between psychotic MDD and anxiety or suicide, with odds ratio of 33.097 for severe anxiety, and 5.012 for suicide. Conclusions Our results suggest that psychotic symptoms are common in MDD patients at their first episode. The strong association between psychotic MDD and anxiety or suicide attempts demonstrates the importance of reducing anxiety symptoms in the treatment of psychotic MDD patients as well as the necessity to regularly assess suicide risk in MDD patients with psychotic symptoms to better prevent suicidal behavior. |
关键词 | clinical correlates cross-sectional study major depressive disorder prevalence psychotic symptom |
2020-05-07 | |
语种 | 英语 |
DOI | 10.1002/da.23026 |
发表期刊 | DEPRESSION AND ANXIETY |
ISSN | 1091-4269 |
页码 | 8 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | Suzhou Clinical Medical Expert Team Introduced Project[SZYJTD201715] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Natural Science Fund Project of Jiangsu Province[BK20151197] |
出版者 | WILEY |
WOS关键词 | RISK-FACTORS ; PERSECUTORY DELUSIONS ; SUICIDE ATTEMPTS ; GLOBAL BURDEN ; UNIPOLAR ; BIPOLAR ; FEATURES ; ANXIETY ; SCALE |
WOS研究方向 | Psychology ; Psychiatry |
WOS类目 | Psychology, Clinical ; Psychiatry ; Psychology |
WOS记录号 | WOS:000530745900001 |
Q分类 | Q1 |
资助机构 | Suzhou Clinical Medical Expert Team Introduced Project ; Suzhou Key Medical Center for Psychiatric Diseases ; Natural Science Fund Project of Jiangsu Province |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31826 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Luo, Xuerong; Zhang, Xiang Yang |
作者单位 | 1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China 2.Cent South Univ, Dept Psychiat,China Natl Clin Res Ctr Mental Diso, China Natl Technol Inst Mental Disorders,Hunan Te, Hunan Key Lab Psychiat & Mental Hlth,Mental Hlth, Changsha, Hunan, Peoples R China 3.Changshu Third Hosp People, Dept Psychiat, Changshu, Jiangsu, Peoples R China 4.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Dept Psychiat, Suzhou, Peoples R China 5.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Psychol Counseling Ctr, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Shen, Yanmei,Wei, Ying,Yang, Xu-Na,et al. Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors[J]. DEPRESSION AND ANXIETY,2020:8. |
APA | Shen, Yanmei.,Wei, Ying.,Yang, Xu-Na.,Zhang, Guangya.,Du, Xiangdong.,...&Zhang, Xiang Yang.(2020).Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors.DEPRESSION AND ANXIETY,8. |
MLA | Shen, Yanmei,et al."Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors".DEPRESSION AND ANXIETY (2020):8. |
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