PSYCH OpenIR  > 中国科学院心理健康重点实验室
Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors
Shen, Yanmei1,2; Wei, Ying3; Yang, Xu-Na4; Zhang, Guangya4; Du, Xiangdong4; Jia, Qiufang4; Zhu, Xiaomin4; Ma, Yuejiao1,2; Lang, XiaoE5; Luo, Xuerong1,2; Zhang, Xiang Yang6,7
First AuthorShen, Yanmei
Correspondent Emailluoxuerong@csu.edu.cn ; zhangxy@psych.ac.cn
2020-05-07
Source PublicationDEPRESSION AND ANXIETY
ISSN1091-4269
Subtypearticle
Pages8
QuartileQ1
Contribution Rank6
Abstract

Background Many patients with major depressive disorder (MDD) have been found to have psychotic symptoms. However, few studies have reported the prevalence of comorbid psychotic symptoms in first-episode drug naive (FEDN) MDD patients. This study was to investigate the prevalence of psychotic symptoms and related risk factors in a large sample size of FEDN MDD patients in a Chinese population. Methods A total of 573 patients with diagnosis of MDD at their first episode were recruited with their demographic and clinical data. Positive scale of the Positive and Negative Syndrome Scale was utilized for psychotic symptoms, Hamilton Anxiety Rating Scale (HAMA) for anxiety symptoms, and Hamilton Depression Rating Scale (HAMD) for depressive symptoms. Results The prevalence of psychotic symptoms in these MDD patients was 9.8%. MDD patients with psychotic symptoms had significantly higher HAMD and HAMA total scores than those without psychotic symptoms (both p < .001). A strong association was found between psychotic MDD and anxiety or suicide, with odds ratio of 33.097 for severe anxiety, and 5.012 for suicide. Conclusions Our results suggest that psychotic symptoms are common in MDD patients at their first episode. The strong association between psychotic MDD and anxiety or suicide attempts demonstrates the importance of reducing anxiety symptoms in the treatment of psychotic MDD patients as well as the necessity to regularly assess suicide risk in MDD patients with psychotic symptoms to better prevent suicidal behavior.

Keywordclinical correlates cross-sectional study major depressive disorder prevalence psychotic symptom
DOI10.1002/da.23026
Indexed BySCI
Language英语
Funding OrganizationSuzhou Clinical Medical Expert Team Introduced Project ; Suzhou Key Medical Center for Psychiatric Diseases ; Natural Science Fund Project of Jiangsu Province
Funding ProjectSuzhou Clinical Medical Expert Team Introduced Project[SZYJTD201715] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Natural Science Fund Project of Jiangsu Province[BK20151197]
WOS Research AreaPsychology ; Psychiatry
WOS SubjectPsychology, Clinical ; Psychiatry ; Psychology
WOS IDWOS:000530745900001
PublisherWILEY
WOS KeywordRISK-FACTORS ; PERSECUTORY DELUSIONS ; SUICIDE ATTEMPTS ; GLOBAL BURDEN ; UNIPOLAR ; BIPOLAR ; FEATURES ; ANXIETY ; SCALE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31826
Collection中国科学院心理健康重点实验室
Corresponding AuthorLuo, Xuerong; Zhang, Xiang Yang
Affiliation1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
2.Cent South Univ, Dept Psychiat,China Natl Clin Res Ctr Mental Diso, China Natl Technol Inst Mental Disorders,Hunan Te, Hunan Key Lab Psychiat & Mental Hlth,Mental Hlth, Changsha, Hunan, Peoples R China
3.Changshu Third Hosp People, Dept Psychiat, Changshu, Jiangsu, Peoples R China
4.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Dept Psychiat, Suzhou, Peoples R China
5.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Psychol Counseling Ctr, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Shen, Yanmei,Wei, Ying,Yang, Xu-Na,et al. Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors[J]. DEPRESSION AND ANXIETY,2020:8.
APA Shen, Yanmei.,Wei, Ying.,Yang, Xu-Na.,Zhang, Guangya.,Du, Xiangdong.,...&Zhang, Xiang Yang.(2020).Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors.DEPRESSION AND ANXIETY,8.
MLA Shen, Yanmei,et al."Psychotic symptoms in first-episode and drug naive patients with major depressive disorder: Prevalence and related clinical factors".DEPRESSION AND ANXIETY (2020):8.
Files in This Item:
File Name/Size DocType Version Access License
Psychotic symptoms i(356KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Psychotic symptoms i(356KB) 限制开放--Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Shen, Yanmei]'s Articles
[Wei, Ying]'s Articles
[Yang, Xu-Na]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shen, Yanmei]'s Articles
[Wei, Ying]'s Articles
[Yang, Xu-Na]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shen, Yanmei]'s Articles
[Wei, Ying]'s Articles
[Yang, Xu-Na]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.