Institutional Repository of Key Laboratory of Behavioral Science, CAS
Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium | |
Long, Yicheng1,2,3; Cao, Hengyi4; Yan, Chaogan5,6,7,8; Chen, Xiao5,6; Li, Le5,6; Castellanos, Francisco Xavier8,9; Bai, Tongjian10; Bo, Qijing11; Chen, Guanmao12; Chen, Ningxuan5,6; Chen, Wei13; Cheng, Chang1; Cheng, Yuqi14; Cui, Xilong1; Duan, Jia15; Fang, Yiru16,17; Gong, Qiyong18; Guo, Wenbin1; Hou, Zhenghua19; Hu, Lan20; Kuang, Li21; Li, Feng11; Li, Kaiming18; Li, Tao21; Liu, Yansong22; Luo, Qinghua20; Meng, Huaqing20; Peng, Daihui16,17; Qiu, Haitang20; Qiu, Jiang23; Shen, Yuedi24; Shi, Yushu25; Si, Tianmei26; Wang, Chuanyue11; Wang, Fei15; Wang, Kai10; Wang, Li26; Wang, Xiang1; Wang, Ying12; Wu, Xiaoping27; Wu, Xinran25; Xie, Chunming28; Xie, Guangrong1; Xie, Haiyan29; Xie, Peng30,31,32; Xu, Xiufeng14; Yang, Hong25; Yang, Jian33; Yao, Jiashu13; Yao, Shuqiao1; Yin, Yingying19; Yuan, Yonggui19; Zhang, Aixia34; Zhang, Hong27; Zhang, Kerang34; Zhang, Lei5,6; Zhang, Zhijun27; Zhou, Rubai16,17; Zhou, Yiting21; Zhu, Junjuan16,17; Zou, Chaojie14; Zang, Yufeng35,36; Zhao, Jingping1; Chan, Calais Kin-yuen37; Pu, Weidan38; Liu, Zhening1,2 | |
摘要 | Background: Major depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed to characterize dynamic FC in MDD using a large multi-site sample and a novel dynamic network-based approach. Methods: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from a total of 460 MDD patients and 473 healthy controls, as a part of the REST-meta-MDD consortium. Resting-state dynamic functional brain networks were constructed for each subject by a sliding-window approach. Multiple spatio-temporal features of dynamic brain networks, including temporal variability, temporal clustering and temporal efficiency, were then compared between patients and healthy subjects at both global and local levels. Results: The group of MDD patients showed significantly higher temporal variability, lower temporal correlation coefficient (indicating decreased temporal clustering) and shorter characteristic temporal path length (indicating increased temporal efficiency) compared with healthy controls (corrected p < 3.14 x 10(-3)). Corresponding local changes in MDD were mainly found in the default-mode, sensorimotor and subcortical areas. Measures of temporal variability and characteristic temporal path length were significantly correlated with depression severity in patients (corrected p < 0.05). Moreover, the observed between-group differences were robustly present in both first-episode, drug-naive (FEDN) and non-FEDN patients. Conclusions: Our findings suggest that excessive temporal variations of brain FC, reflecting abnormal communications between large-scale bran networks over time, may underlie the neuropathology of MDD. |
关键词 | Depression Default-mode FMRI Dynamic functional connectivity Connectome Temporal variability |
2020 | |
语种 | 英语 |
DOI | 10.1016/j.nicl.2020.102163 |
发表期刊 | NEUROIMAGE-CLINICAL |
ISSN | 2213-1582 |
卷号 | 26页码:9 |
收录类别 | SCI |
资助项目 | China Precision Medicine Initiative[2016YFC0906300] ; National Natural Science Foundation of China[81561168021] ; National Natural Science Foundation of China[81671335] ; National Natural Science Foundation of China[81701325] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[81801353] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Brain and Behavioral Research Foundation NARSAD Young Investigator Grant[27068] |
出版者 | ELSEVIER SCI LTD |
WOS关键词 | CONNECTIVITY ; RECONFIGURATION ; SCHIZOPHRENIA ; VARIABILITY |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neuroimaging |
WOS记录号 | WOS:000533149400011 |
资助机构 | China Precision Medicine Initiative ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Brain and Behavioral Research Foundation NARSAD Young Investigator Grant |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31841 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Cao, Hengyi; Liu, Zhening |
作者单位 | 1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China 2.Cent South Univ, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China 3.Yale Univ, Dept Psychiat, Sch Med, New Haven, CT 06511 USA 4.Yale Univ, Dept Psychol, 2 Hillhouse Ave, New Haven, CT 06511 USA 5.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr & Res Ctr Lifesp, Inst Psychol, Beijing 100101, Peoples R China 8.NYU, Dept Child & Adolescent Psychiat, Sch Med, New York, NY 10016 USA 9.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA 10.Anhui Med Univ, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China 11.Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China 12.Jinan Univ, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China 13.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China 14.Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China 15.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang 110001, Liaoning, Peoples R China 16.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Clin Res Ctr, Sch Med, Shanghai 200030, Peoples R China 17.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Div Mood Disorders, Sch Med, Shanghai 200030, Peoples R China 18.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr, Chengdu 610041, Sichuan, Peoples R China 19.Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing 210096, Jiangsu, Peoples R China 20.Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China 21.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610041, Sichuan, Peoples R China 22.Soochow Univ, Suzhou Psychiat Hosp, Dept Clin Psychol, Affiliated Guangji Hosp, Suzhou 215137, Jiangsu, Peoples R China 23.Southwest Univ, Fac Psychol, Chongqing 400716, Peoples R China 24.Hangzhou Normal Univ, Affiliated Hosp, Med Sch, Dept Diagnost, Hangzhou 311121, Zhejiang, Peoples R China 25.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou 310058, Zhejiang, Peoples R China 26.Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing 100191, Peoples R China 27.Xian Cent Hosp, Xian 710003, Shaanxi, Peoples R China 28.Southeast Univ, Dept Neurol, Affiliated Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China 29.Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Hangzhou 310058, Zhejiang, Peoples R China 30.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China 31.Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China 32.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China 33.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China 34.Shanxi Med Univ, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China 35.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Inst Psychol Sci, Hangzhou 311121, Zhejiang, Peoples R China 36.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 311121, Zhejiang, Peoples R China 37.Univ Hong Kong, Dept Psychol, Hong Kong 999077, Peoples R China 38.Cent South Univ, Xiangya Hosp 2, Med Psychol Inst, Changsha 410011, Hunan, Peoples R China |
推荐引用方式 GB/T 7714 | Long, Yicheng,Cao, Hengyi,Yan, Chaogan,et al. Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium[J]. NEUROIMAGE-CLINICAL,2020,26:9. |
APA | Long, Yicheng.,Cao, Hengyi.,Yan, Chaogan.,Chen, Xiao.,Li, Le.,...&Liu, Zhening.(2020).Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium.NEUROIMAGE-CLINICAL,26,9. |
MLA | Long, Yicheng,et al."Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium".NEUROIMAGE-CLINICAL 26(2020):9. |
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