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Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium
Long, Yicheng1,2,3; Cao, Hengyi4; Yan, Chaogan5,6,7,8; Chen, Xiao5,6; Li, Le5,6; Castellanos, Francisco Xavier8,9; Bai, Tongjian10; Bo, Qijing11; Chen, Guanmao12; Chen, Ningxuan5,6; Chen, Wei13; Cheng, Chang1; Cheng, Yuqi14; Cui, Xilong1; Duan, Jia15; Fang, Yiru16,17; Gong, Qiyong18; Guo, Wenbin1; Hou, Zhenghua19; Hu, Lan20; Kuang, Li21; Li, Feng11; Li, Kaiming18; Li, Tao21; Liu, Yansong22; Luo, Qinghua20; Meng, Huaqing20; Peng, Daihui16,17; Qiu, Haitang20; Qiu, Jiang23; Shen, Yuedi24; Shi, Yushu25; Si, Tianmei26; Wang, Chuanyue11; Wang, Fei15; Wang, Kai10; Wang, Li26; Wang, Xiang1; Wang, Ying12; Wu, Xiaoping27; Wu, Xinran25; Xie, Chunming28; Xie, Guangrong1; Xie, Haiyan29; Xie, Peng30,31,32; Xu, Xiufeng14; Yang, Hong25; Yang, Jian33; Yao, Jiashu13; Yao, Shuqiao1; Yin, Yingying19; Yuan, Yonggui19; Zhang, Aixia34; Zhang, Hong27; Zhang, Kerang34; Zhang, Lei5,6; Zhang, Zhijun27; Zhou, Rubai16,17; Zhou, Yiting21; Zhu, Junjuan16,17; Zou, Chaojie14; Zang, Yufeng35,36; Zhao, Jingping1; Chan, Calais Kin-yuen37; Pu, Weidan38; Liu, Zhening1,2
2020
Source PublicationNEUROIMAGE-CLINICAL
ISSN2213-1582
Volume26Pages:9
Abstract

Background: Major depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed to characterize dynamic FC in MDD using a large multi-site sample and a novel dynamic network-based approach. Methods: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from a total of 460 MDD patients and 473 healthy controls, as a part of the REST-meta-MDD consortium. Resting-state dynamic functional brain networks were constructed for each subject by a sliding-window approach. Multiple spatio-temporal features of dynamic brain networks, including temporal variability, temporal clustering and temporal efficiency, were then compared between patients and healthy subjects at both global and local levels. Results: The group of MDD patients showed significantly higher temporal variability, lower temporal correlation coefficient (indicating decreased temporal clustering) and shorter characteristic temporal path length (indicating increased temporal efficiency) compared with healthy controls (corrected p < 3.14 x 10(-3)). Corresponding local changes in MDD were mainly found in the default-mode, sensorimotor and subcortical areas. Measures of temporal variability and characteristic temporal path length were significantly correlated with depression severity in patients (corrected p < 0.05). Moreover, the observed between-group differences were robustly present in both first-episode, drug-naive (FEDN) and non-FEDN patients. Conclusions: Our findings suggest that excessive temporal variations of brain FC, reflecting abnormal communications between large-scale bran networks over time, may underlie the neuropathology of MDD.

KeywordDepression Default-mode FMRI Dynamic functional connectivity Connectome Temporal variability
DOI10.1016/j.nicl.2020.102163
Indexed BySCI
Language英语
Funding OrganizationChina Precision Medicine Initiative ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Brain and Behavioral Research Foundation NARSAD Young Investigator Grant
Funding ProjectChina Precision Medicine Initiative[2016YFC0906300] ; National Natural Science Foundation of China[81561168021] ; National Natural Science Foundation of China[81671335] ; National Natural Science Foundation of China[81701325] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[81801353] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Brain and Behavioral Research Foundation NARSAD Young Investigator Grant[27068]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000533149400011
PublisherELSEVIER SCI LTD
WOS KeywordCONNECTIVITY ; RECONFIGURATION ; SCHIZOPHRENIA ; VARIABILITY
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31841
Collection中国科学院行为科学重点实验室
Corresponding AuthorCao, Hengyi; Liu, Zhening
Affiliation1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
2.Cent South Univ, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
3.Yale Univ, Dept Psychiat, Sch Med, New Haven, CT 06511 USA
4.Yale Univ, Dept Psychol, 2 Hillhouse Ave, New Haven, CT 06511 USA
5.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr & Res Ctr Lifesp, Inst Psychol, Beijing 100101, Peoples R China
8.NYU, Dept Child & Adolescent Psychiat, Sch Med, New York, NY 10016 USA
9.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
10.Anhui Med Univ, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
11.Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China
12.Jinan Univ, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China
13.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China
14.Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China
15.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang 110001, Liaoning, Peoples R China
16.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Clin Res Ctr, Sch Med, Shanghai 200030, Peoples R China
17.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Div Mood Disorders, Sch Med, Shanghai 200030, Peoples R China
18.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr, Chengdu 610041, Sichuan, Peoples R China
19.Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing 210096, Jiangsu, Peoples R China
20.Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China
21.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610041, Sichuan, Peoples R China
22.Soochow Univ, Suzhou Psychiat Hosp, Dept Clin Psychol, Affiliated Guangji Hosp, Suzhou 215137, Jiangsu, Peoples R China
23.Southwest Univ, Fac Psychol, Chongqing 400716, Peoples R China
24.Hangzhou Normal Univ, Affiliated Hosp, Med Sch, Dept Diagnost, Hangzhou 311121, Zhejiang, Peoples R China
25.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou 310058, Zhejiang, Peoples R China
26.Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing 100191, Peoples R China
27.Xian Cent Hosp, Xian 710003, Shaanxi, Peoples R China
28.Southeast Univ, Dept Neurol, Affiliated Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China
29.Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Hangzhou 310058, Zhejiang, Peoples R China
30.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China
31.Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China
32.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China
33.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China
34.Shanxi Med Univ, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China
35.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Inst Psychol Sci, Hangzhou 311121, Zhejiang, Peoples R China
36.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 311121, Zhejiang, Peoples R China
37.Univ Hong Kong, Dept Psychol, Hong Kong 999077, Peoples R China
38.Cent South Univ, Xiangya Hosp 2, Med Psychol Inst, Changsha 410011, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Long, Yicheng,Cao, Hengyi,Yan, Chaogan,et al. Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium[J]. NEUROIMAGE-CLINICAL,2020,26:9.
APA Long, Yicheng.,Cao, Hengyi.,Yan, Chaogan.,Chen, Xiao.,Li, Le.,...&Liu, Zhening.(2020).Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium.NEUROIMAGE-CLINICAL,26,9.
MLA Long, Yicheng,et al."Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium".NEUROIMAGE-CLINICAL 26(2020):9.
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