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A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease
Fu, Xiaoxue1; Wang, Yu3; He, Xiaofeng4; Li, Hongyu1; Liu, Hong1; Zhang, Xiangyang2,5
First AuthorFu, Xiaoxue
Correspondent Emailyujian80@163.com ; zhangxy9@gmail.com
2020-05-19
Source PublicationLIPIDS IN HEALTH AND DISEASE
Subtypearticle
Volume19Issue:1Pages:10
Contribution Rank2
Abstract

Objectives Numerous studies have reported that lipid metabolic abnormalities may play an important role in the development of Parkinson's disease (PD), with mixed results. This meta-analysis aims to systematically assess the relationship between serum cholesterol or triglyceride and the PD risk and to further determine the role of dyslipidemia in potential predictive value. Methods This research systematically consulted and screened observational studies to evaluate the association of serum lipids with the risk of PD as of April 01, 2020 based on the inclusion and exclusion criteria. Two researchers screened and extracted the data independently. Then this article summarized the characteristics of all clinical studies and collected the corresponding data to perform pooled and sensitivity analyses. The meta-analysis was performed by using the RevMan 5.3 software after data extraction, quality assessment and analysis of publication bias. Results Twenty-one related studies (13 case-control and 8 cohort studies) were selected with a total of 980,180 subjects, including 11,188 PD patients. Meta-analysis showed that higher levels of serum triglyceride (S-TG) [standard mean different (SMD) = - 0.26 (95% confidence interval (CI): - 0.39 to - 0.13, p<0.00001), relative risk (RR) = 0.67 (95% CI: 0.60 to 0.75, p<0.00001)] could be considered as protective factors for the pathogenesis of PD. However, there was no significant association between serum high density lipoprotein cholesterol (S-HDL) and the risk of PD. Meanwhile, serum low density lipoprotein cholesterol (S-LDL) [SMD = -0.26 (95% CI: - 0.43 to - 0.07, p = 0.006), RR = 0.76 (95% CI: 0.59 to 0.97, p = 0.03)] and serum total cholesterol (S-TC) levels [SMD = -0.21 (95% CI: - 0.33 to - 0.10, p = 0.0002), RR = 0.86 (95% CI: 0.77 to 0.97, p = 0.01)] were negatively associated with PD risk. Conclusions This systematic review suggests that elevated serum levels of TG, LDL and TC may be protective factors for the pathogenesis of PD. Further longitudinal and well-designed prospective studies with a large sample size are needed to confirm the findings in this meta-analysis.

KeywordMeta-analysis Systematic review Parkinson's disease Triglyceride Low density lipoprotein cholesterol Total cholesterol
DOI10.1186/s12944-020-01284-w
Indexed BySCI
Language英语
Funding OrganizationTianjin Natural Science Foundation
Funding ProjectTianjin Natural Science Foundation[17JCYBJC28100]
WOS Research AreaBiochemistry & Molecular Biology ; Nutrition & Dietetics
WOS SubjectBiochemistry & Molecular Biology ; Nutrition & Dietetics
WOS IDWOS:000536773000002
PublisherBMC
WOS KeywordALPHA-SYNUCLEIN ; RISK-FACTORS ; TYROSINE-HYDROXYLASE ; OXIDATIVE STRESS ; BRAIN ; STATINS ; 27-HYDROXYCHOLESTEROL ; EXCITOTOXICITY ; DEGENERATION ; PATHOGENESIS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31961
Collection中国科学院心理健康重点实验室
Corresponding AuthorLiu, Hong; Zhang, Xiangyang
Affiliation1.Changzhi Med Coll, Heping Hosp, Changzhi, Shanxi, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Tianjin Med Univ, Dept Neurol, Gen Hosp, Tianjin, Peoples R China
4.Changzhi Med Coll, Dept Sci & Educ, Heping Hosp, Changzhi City, Shanxi, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Fu, Xiaoxue,Wang, Yu,He, Xiaofeng,et al. A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease[J]. LIPIDS IN HEALTH AND DISEASE,2020,19(1):10.
APA Fu, Xiaoxue,Wang, Yu,He, Xiaofeng,Li, Hongyu,Liu, Hong,&Zhang, Xiangyang.(2020).A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease.LIPIDS IN HEALTH AND DISEASE,19(1),10.
MLA Fu, Xiaoxue,et al."A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease".LIPIDS IN HEALTH AND DISEASE 19.1(2020):10.
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