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Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers | |
Shi, Jun-Yan1,2,3; Wang, Ping1,5; Wang, Bin-Hong2,3; Xu, Yong4; Chen, Xiao1,5; Li, Hui-Jie1,5 | |
第一作者 | Shi, Jun-Yan |
通讯作者邮箱 | lihj@psych.ac.cn (h.-j. li) |
心理所单位排序 | 1 |
摘要 | Individuals with mild cognitive impairment (MCI) are regarded as being at high risk of developing Alzheimer's disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is a well-established genetic risk factor for developing AD. In the present study, by using voxel-mirrored homotopic connectivity (VMHC), we aimed to explore the potential functional disruptions in MCI APOE-epsilon 4 carriers. Resting-state functional magnetic resonance imaging was performed in 35 MCI APOE-epsilon 4 carriers (27 APOE-epsilon 3 epsilon 4, 8 APOE-epsilon 4 epsilon 4) and 42 MCI APOE-epsilon 4 noncarriers (APOE-epsilon 3 epsilon 3). VMHC was employed to investigate the alterations in functional connectivity in MCI APOE-epsilon 4 carriers. We further investigated the seed-based functional connectivity between the VMHC values of altered regions and other brain regions in the two groups. The results showed that MCI APOE-epsilon 4 carriers presented increased VMHC in the inferior frontal gyrus/insula and middle frontal gyrus/superior frontal gyrus in comparison with noncarriers. We found that MCI APOE-epsilon 4 carriers showed increased functional connectivity between the seed regions (bilateral inferior frontal gyri/insula and bilateral middle frontal gyri/superior frontal gyri) and broad brain areas, including the frontal, temporal, parietal, and cerebellar regions. Our findings provide neuroimaging evidence for the modulation of the APOE genotype on the neurodegenerative disease phenotype and may be potentially important for monitoring disease progression in double-high-risk populations of AD. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved. |
关键词 | mild cognitive impairment apolipoprotein E connectivity fMRI |
2020-06-01 | |
语种 | 英语 |
DOI | 10.1016/j.neuroscience.2020.04.011 |
发表期刊 | NEUROSCIENCE |
ISSN | 0306-4522 |
卷号 | 436页码:74-81 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31871143] ; Chinese Academy of Sciences Youth Innovation Promotion Association, China[2016084] |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS关键词 | APOLIPOPROTEIN-E EPSILON-4 ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; SYSTEMS NEUROSCIENCE ; YOUNG CARRIERS ; APOE GENOTYPE ; ALLELE ; ASSOCIATION ; VOLUME |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000536491900006 |
Q分类 | Q2 |
资助机构 | National Natural Science Foundation of China ; Chinese Academy of Sciences Youth Innovation Promotion Association, China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31964 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Li, Hui-Jie |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Psychiat Hosp Taiyuan City, Taiyuan 030000, Peoples R China 3.Shanxi Mental Hlth Ctr, Dept Med Psychol, Taiyuan 030000, Peoples R China 4.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan 030001, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
第一作者单位 | 中国科学院行为科学重点实验室 |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,et al. Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers[J]. NEUROSCIENCE,2020,436:74-81. |
APA | Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,Xu, Yong,Chen, Xiao,&Li, Hui-Jie.(2020).Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers.NEUROSCIENCE,436,74-81. |
MLA | Shi, Jun-Yan,et al."Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers".NEUROSCIENCE 436(2020):74-81. |
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