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Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers
Shi, Jun-Yan1,2,3; Wang, Ping1,5; Wang, Bin-Hong2,3; Xu, Yong4; Chen, Xiao1,5; Li, Hui-Jie1,5
第一作者Shi, Jun-Yan
通讯作者邮箱lihj@psych.ac.cn (h.-j. li)
心理所单位排序1
摘要

Individuals with mild cognitive impairment (MCI) are regarded as being at high risk of developing Alzheimer's disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is a well-established genetic risk factor for developing AD. In the present study, by using voxel-mirrored homotopic connectivity (VMHC), we aimed to explore the potential functional disruptions in MCI APOE-epsilon 4 carriers. Resting-state functional magnetic resonance imaging was performed in 35 MCI APOE-epsilon 4 carriers (27 APOE-epsilon 3 epsilon 4, 8 APOE-epsilon 4 epsilon 4) and 42 MCI APOE-epsilon 4 noncarriers (APOE-epsilon 3 epsilon 3). VMHC was employed to investigate the alterations in functional connectivity in MCI APOE-epsilon 4 carriers. We further investigated the seed-based functional connectivity between the VMHC values of altered regions and other brain regions in the two groups. The results showed that MCI APOE-epsilon 4 carriers presented increased VMHC in the inferior frontal gyrus/insula and middle frontal gyrus/superior frontal gyrus in comparison with noncarriers. We found that MCI APOE-epsilon 4 carriers showed increased functional connectivity between the seed regions (bilateral inferior frontal gyri/insula and bilateral middle frontal gyri/superior frontal gyri) and broad brain areas, including the frontal, temporal, parietal, and cerebellar regions. Our findings provide neuroimaging evidence for the modulation of the APOE genotype on the neurodegenerative disease phenotype and may be potentially important for monitoring disease progression in double-high-risk populations of AD. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

关键词mild cognitive impairment apolipoprotein E connectivity fMRI
2020-06-01
语种英语
DOI10.1016/j.neuroscience.2020.04.011
发表期刊NEUROSCIENCE
ISSN0306-4522
卷号436页码:74-81
期刊论文类型article
收录类别SCI
资助项目National Natural Science Foundation of China[31871143] ; Chinese Academy of Sciences Youth Innovation Promotion Association, China[2016084]
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词APOLIPOPROTEIN-E EPSILON-4 ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; SYSTEMS NEUROSCIENCE ; YOUNG CARRIERS ; APOE GENOTYPE ; ALLELE ; ASSOCIATION ; VOLUME
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000536491900006
Q分类Q2
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences Youth Innovation Promotion Association, China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/31964
专题中国科学院行为科学重点实验室
通讯作者Li, Hui-Jie
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Psychiat Hosp Taiyuan City, Taiyuan 030000, Peoples R China
3.Shanxi Mental Hlth Ctr, Dept Med Psychol, Taiyuan 030000, Peoples R China
4.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan 030001, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
第一作者单位中国科学院行为科学重点实验室
通讯作者单位中国科学院行为科学重点实验室
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Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,et al. Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers[J]. NEUROSCIENCE,2020,436:74-81.
APA Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,Xu, Yong,Chen, Xiao,&Li, Hui-Jie.(2020).Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers.NEUROSCIENCE,436,74-81.
MLA Shi, Jun-Yan,et al."Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers".NEUROSCIENCE 436(2020):74-81.
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