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Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers
Shi, Jun-Yan1,2,3; Wang, Ping1,5; Wang, Bin-Hong2,3; Xu, Yong4; Chen, Xiao1,5; Li, Hui-Jie1,5
First AuthorShi, Jun-Yan
Correspondent Emaillihj@psych.ac.cn (h.-j. li)
Contribution Rank1
Abstract

Individuals with mild cognitive impairment (MCI) are regarded as being at high risk of developing Alzheimer's disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is a well-established genetic risk factor for developing AD. In the present study, by using voxel-mirrored homotopic connectivity (VMHC), we aimed to explore the potential functional disruptions in MCI APOE-epsilon 4 carriers. Resting-state functional magnetic resonance imaging was performed in 35 MCI APOE-epsilon 4 carriers (27 APOE-epsilon 3 epsilon 4, 8 APOE-epsilon 4 epsilon 4) and 42 MCI APOE-epsilon 4 noncarriers (APOE-epsilon 3 epsilon 3). VMHC was employed to investigate the alterations in functional connectivity in MCI APOE-epsilon 4 carriers. We further investigated the seed-based functional connectivity between the VMHC values of altered regions and other brain regions in the two groups. The results showed that MCI APOE-epsilon 4 carriers presented increased VMHC in the inferior frontal gyrus/insula and middle frontal gyrus/superior frontal gyrus in comparison with noncarriers. We found that MCI APOE-epsilon 4 carriers showed increased functional connectivity between the seed regions (bilateral inferior frontal gyri/insula and bilateral middle frontal gyri/superior frontal gyri) and broad brain areas, including the frontal, temporal, parietal, and cerebellar regions. Our findings provide neuroimaging evidence for the modulation of the APOE genotype on the neurodegenerative disease phenotype and may be potentially important for monitoring disease progression in double-high-risk populations of AD. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Keywordmild cognitive impairment apolipoprotein E connectivity fMRI
2020-06-01
Language英语
DOI10.1016/j.neuroscience.2020.04.011
Source PublicationNEUROSCIENCE
ISSN0306-4522
Volume436Pages:74-81
Subtypearticle
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31871143] ; Chinese Academy of Sciences Youth Innovation Promotion Association, China[2016084]
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordAPOLIPOPROTEIN-E EPSILON-4 ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; SYSTEMS NEUROSCIENCE ; YOUNG CARRIERS ; APOE GENOTYPE ; ALLELE ; ASSOCIATION ; VOLUME
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000536491900006
QuartileQ2
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31964
Collection中国科学院行为科学重点实验室
Corresponding AuthorLi, Hui-Jie
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Psychiat Hosp Taiyuan City, Taiyuan 030000, Peoples R China
3.Shanxi Mental Hlth Ctr, Dept Med Psychol, Taiyuan 030000, Peoples R China
4.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan 030001, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,et al. Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers[J]. NEUROSCIENCE,2020,436:74-81.
APA Shi, Jun-Yan,Wang, Ping,Wang, Bin-Hong,Xu, Yong,Chen, Xiao,&Li, Hui-Jie.(2020).Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers.NEUROSCIENCE,436,74-81.
MLA Shi, Jun-Yan,et al."Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-epsilon 4 Carriers".NEUROSCIENCE 436(2020):74-81.
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