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Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies
Zhang, Chun-Jing1; Guo, Jian-You2; Cheng, Hao3; Lin, Li4; Liu, Ying1; Shi, Yan1; Xu, Jing1; Yu, Hai-Tao5
First AuthorZhang, Chun-Jing
Correspondent Emailyht422@126.com
Contribution Rank2
Abstract

Pleurotus eryngii (PE) contains polysaccharides and vitamins, and has been reported to have antidepression properties. P. eryngii polysaccharides (PEP) are one of the main components. Modulation of beta-amyloid-induced neurotoxicity has emerged as a possible therapeutic approach to ameliorate the onset and progression of Alzheimer's disease (AD). The present study aimed to evaluate the protective effect of PEP on beta-amyloid-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells and aging rats. After 28 weeks' treatment, exposure of PC12 cells to P. eryngii polysaccharides significantly elevated cell viability, decreased the levels of intracellular calcium, and attenuated the beta-amyloid-mediated cell apoptosis. In aging rats, P. eryngii polysaccharides could decrease the production of APP in the brain by an action that is associated with a lowering of the iNOS, and COX-2 level. Our findings indicated that P. eryngii polysaccharides had potential neuroprotective actions against beta-amyloid-induced neurotoxicity, which might be through modulating calcium channels, or downstream molecules involved in inflammation.

KeywordPleurotus eryngii polysaccharides Alzheimer's disease beta-amyloid PC12 cells neuroprotection medicinal mushrooms
2020
Language英语
DOI10.1615/IntJMedMushrooms.2020033990
Source PublicationINTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
ISSN1521-9437
Volume22Issue:4Pages:325-333
Subtypearticle
Indexed BySCI
Funding ProjectPostdoctoral Researcher of Heilongjiang Postdoctoral Management Office[LBH-Q16225] ; Qiqihar Medical University[QY2016LX-01]
PublisherBEGELL HOUSE INC
WOS KeywordNITRIC-OXIDE SYNTHASE ; CYCLOOXYGENASE-2 ; APOPTOSIS ; PRECURSOR ; EXTRACT ; PROTEIN
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy
WOS IDWOS:000536225900002
QuartileQ4
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31976
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Hai-Tao
Affiliation1.Qiqihar Med Univ, Dept Biochem, Qiqihar 161006, Heilongjiang, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
3.Qiqihar Med Univ, Affiliated Hosp 3, Qiqihar 161006, Heilongjiang, Peoples R China
4.Qiqihar Med Univ, Dept Clin Biochem, Qiqihar 161006, Heilongjiang, Peoples R China
5.Qiqihar Med Univ, Dept Biol Genet, Qiqihar 161006, Heilongjiang, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Chun-Jing,Guo, Jian-You,Cheng, Hao,et al. Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies[J]. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2020,22(4):325-333.
APA Zhang, Chun-Jing.,Guo, Jian-You.,Cheng, Hao.,Lin, Li.,Liu, Ying.,...&Yu, Hai-Tao.(2020).Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,22(4),325-333.
MLA Zhang, Chun-Jing,et al."Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on beta-Amyloid-lnduced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies".INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 22.4(2020):325-333.
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