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Memory Retrieval-Extinction Combined With Virtual Reality Reducing Drug Craving for Methamphetamine: Study Protocol for a Randomized Controlled Trial
Liu, Wang1,2; Chen, Xi-Jing1; Wen, Ya-Tong1,2; Winkler, Markus H.3; Paul, Pauli3; He, Yi-Ling4; Wang, Liang1,2; Chen, Hong-Xian5; Li, Yong-Hui1,2
2020-04-29
Source PublicationFRONTIERS IN PSYCHIATRY
ISSN1664-0640
Volume11Pages:9
Abstract

Background Relapse, often precipitated by drug-associated cues that evoke craving, is a key problem in the treatment of methamphetamine use disorder (MUD). Drug-associated memories play a major role in the maintenance of relapse. Extinction training is a common method for decreasing drug craving by suppressing drug-associated memories. However, the effects are often not permanent, which is evident in form of spontaneous recovery or renewal of cue-elicited responses. Based on memory reconsolidation theory, the retrieval-extinction (R-E) paradigm may be more effective in decreasing spontaneous recovery or renewal responses than extinction. After the original memory reactivated to a labile state, extinction will be introduced within the reconsolidation window, thereby updating drug-associated memories. However, there are still some controversial results, which suggest that the reactivation of drug-associated memories and the 10 min-6 h of limited time window are two main elements in the R-E protocol. Virtual reality (VR) is supposed to promote memory reactivation by providing vivid drug-related stimuli when compared with movies. Objective The aim of this study is to examine the effectiveness of R-E training combined with VR on reducing spontaneous recovery or renewal of cue-elicited responses, in comparison to extinction, R-E training provided outside the time window of 6 h and R-E training retrieved using videos, in methamphetamine abusers. Methods The study is a parallel matched controlled study including 95 participants with MUD. Participants will be randomly assigned to either a R-10 min-E group (methamphetamine-related cues retrieval in VR followed by extinction after 10 min) or a NR-10 min-E group (neutral cues retrieval in VR followed by extinction after 10 min) or a R-6 h-E group (methamphetamine-related cues retrieval in VR followed by extinction after 6 h) or a RV-10 min-E group (methamphetamine-related cues retrieval in videos followed by extinction after 10 min). Cue-evoked craving and reactivity will be assessed at pre-test and at 1 day, 1 week, 1 month, and 6-month post-tests. Discussion To our knowledge, this study will probably be the first study to examine the efficacy of R-E training combined with VR to reduce cue-evoked responses in people with MUD. This innovative non-pharmacological intervention targeting drug-associated memories may provide significant clinical implications for reducing relapse, providing the study confirms its efficacy.

Keywordmemory reconsolidation retrieval-extinction extinction drug-associated memories virtual reality methamphetamine
DOI10.3389/fpsyt.2020.00322
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; Beijing Municipal Science and Technology Commission ; National Natural Science Foundation of China ; CAS Key Lab of Mental Health, Institute of Psychology
Funding ProjectNational Key Research and Development Program of China[2017YFC1310405] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; National Natural Science Foundation of China[U1736124] ; CAS Key Lab of Mental Health, Institute of Psychology
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000535574000001
PublisherFRONTIERS MEDIA SA
WOS KeywordHEART-RATE-VARIABILITY ; DISRUPTING RECONSOLIDATION ; COCAINE-SEEKING ; CUE-EXPOSURE ; RELAPSE ; ADDICTION ; FEAR ; INTERVENTION ; METAANALYSIS ; CONTEXT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/31982
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Yong-Hui
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Univ Wurzburg, Dept Psychol Biol Psychol Clin Psychol & Psychoth, Wurzburg, Germany
4.Womens Drug Rehabil Ctr Guangdong Prov, Ctr Mental Hlth, Foshan, Peoples R China
5.Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liu, Wang,Chen, Xi-Jing,Wen, Ya-Tong,et al. Memory Retrieval-Extinction Combined With Virtual Reality Reducing Drug Craving for Methamphetamine: Study Protocol for a Randomized Controlled Trial[J]. FRONTIERS IN PSYCHIATRY,2020,11:9.
APA Liu, Wang.,Chen, Xi-Jing.,Wen, Ya-Tong.,Winkler, Markus H..,Paul, Pauli.,...&Li, Yong-Hui.(2020).Memory Retrieval-Extinction Combined With Virtual Reality Reducing Drug Craving for Methamphetamine: Study Protocol for a Randomized Controlled Trial.FRONTIERS IN PSYCHIATRY,11,9.
MLA Liu, Wang,et al."Memory Retrieval-Extinction Combined With Virtual Reality Reducing Drug Craving for Methamphetamine: Study Protocol for a Randomized Controlled Trial".FRONTIERS IN PSYCHIATRY 11(2020):9.
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