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Amygdala–prefrontal connectivity modulates loss aversion bias in anxious individuals
Xu, Pengfei1,2,3,4; Van Dam, Nicholas T.5; van Tol, Marie-José3; Shen, Xueyi6; Cui, Zaixu7; Gu, Ruolei8,9; Qin, Shaozheng6; Aleman, André1,3,10; Fan, Jin11; Luo, Yue-jia1,2
First AuthorXu, Pengfei
Correspondent Emailluoyj@szu.edu.cn ; jin.fan@qc.cuny.edu
2020-05-14
Source PublicationNeuroImage
ISSN1095-9572
Subtypearticle
Volume218Pages:116957
QuartileQ1
Contribution Rank8
Abstract

Anxious individuals tend to make pessimistic judgments in decision making under uncertainty. While this phenomenon is commonly attributed to risk aversion, loss aversion is a critical but often overlooked factor. In this study, we simultaneously examined risk aversion and loss aversion during decision making in high and low trait anxious individuals in a variable gain/loss gambling task during functional magnetic resonance imaging. Although high relative to low anxious individuals showed significant increased risk aversive behavior reflected by decreased overall gamble decisions, there was no group difference in subjective aversion to risk. Instead, loss aversion rather than risk aversion dominantly contributed to predict behavioral decisions, which was associated with attenuated functional connectivity between the amygdala-based emotional system and the prefrontal control regions. Our findings suggest a dominant role of loss aversion in maladaptive risk assessment of anxious individuals, underpinned by disorganization of emotion-related and cognitive-control-related brain networks.

KeywordTrait anxiety Decision making Loss aversion Risk aversion Amygdala Prefrontal cortex
DOI10.1016/j.neuroimage.2020.116957
URL查看原文
Indexed BySCIE
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32012
Collection中国科学院心理研究所
Corresponding AuthorFan, Jin; Luo, Yue-jia
Affiliation1.Shenzhen Key Lahoratory of Affective and Social Neuroscience, Center for Brain Disorders and Cognitive Sciences, Shenzhen University, Shenzhen, 518060, China
2.Center for Emotion and Brain, Shenzhen Institute of Neuroscience, Shenzhen, 518057, China
3.Cognitive Neuroscience Center, Department of Biomedical Sciences of Cells and Systems, University Medical Center Gron University of Groningen, 9713 AW, Groningen, the Netherlands
4.Great Bay Neuroscience and Technology Research Institute (Hong Kong) Kwun Tong, Hong, Hong Kong, China
5.School of Psychological Sciences, University of Melhourne, Victoria, 3010, Australia
6.National Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Resem-ch, Beijing Normal University, Beijing 100875, China
7.Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
8.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
9.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
10.Department of Psychology, University of Groningen, the Netherlands
11.Deparunent of Psychology, Queens College, The City University of New York, Flushing NY, 11367, USA
Recommended Citation
GB/T 7714
Xu, Pengfei,Van Dam, Nicholas T.,van Tol, Marie-José,等. Amygdala–prefrontal connectivity modulates loss aversion bias in anxious individuals[J]. NeuroImage,2020,218:116957.
APA Xu, Pengfei.,Van Dam, Nicholas T..,van Tol, Marie-José.,Shen, Xueyi.,Cui, Zaixu.,...&Luo, Yue-jia.(2020).Amygdala–prefrontal connectivity modulates loss aversion bias in anxious individuals.NeuroImage,218,116957.
MLA Xu, Pengfei,et al."Amygdala–prefrontal connectivity modulates loss aversion bias in anxious individuals".NeuroImage 218(2020):116957.
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