PSYCH OpenIR  > 认知与发展心理学研究室
肠道屏障损伤及细菌移位在焦虑抑郁症诱导退行性神经症中的机制
Alternative TitleMechanism of gut barrier inj ury and bacterial translocation in anxiety-depression induced degenerative neurosis
杨路1,2; 董婷婷3; 凌燕3; 吕艳霞3; 禤宇明1,2
First Author杨路
Correspondent Emailxuanym@psychac.cn (禤宇明)
Contribution Rank1
Abstract

肠道屏障是脑-肠道交互作用的晴雨表。健全的肠道屏障对于维系肠道内微生态,抵御外源性病原体的侵入至关重要。焦虑抑郁症能够损害肠道屏障,破坏肠道菌群平衡。肠道屏障损伤引起肠道渗透性升高,肠腔细菌移位,促使外源性病原体进入血液循环和神经系统,启动系统性炎症反应。炎症反应对脑神经的损伤是诱导阿尔茨海默病和帕金森症发生、发展的主要原因。肠道屏障损伤还会破坏原有的肠道菌群结构,造成肠道菌群失调,不仅进一步损伤肠道屏障,还影响神经组织的结构和功能,是阿尔茨海默病和帕金森症形成的另一因素。此综述依据近年来的相关研究,从肠道屏障损伤的角度阐述了焦虑抑郁症触发退行性神经症的机制,强调维护肠道屏障功能在预防退行性神经疾病中具有重要的临床意义。

Other Abstract

The intestinal barrier is a barometer for brain-gut interactions. A healthy intestinal barrier is crucial to maintain the intestinal microecology and resist the invasion of exogenous pathogens. Anxiety and depression can damage the intestinal barrier and destroy the balance of gut flora. The destruction of intestinal harrier intestinal permeability, promotes bacterial translocation and invasion of exogenous pathogens that initiate systemic inflammatory response. The damage of the cerebral nerve caused by the inflammatory reaction is an important reason for the onset and development of Alzheimer's disease (AD) and Parkinson's disease (PD). In addition, the injured intestinal barrier changes original intestinal flora species and results in an imbalance of gut microbiome, which not only increasingly damages the intestinal barrier but also affects the structure and function of nerve tissue. It may contribute to the formation of degenerative neurosis such as AD and PD. Based upon recent researches on intestinal barrier and microbiome-gut-brain MUB communication review tries to explain the mechanism of anxiety and depression triggered degenerative neurosis and emphasizes the clinical significance of gut barrier function in prevention of degenerative neurological diseases.

Keyword肠道屏障 菌群失调 细菌移位 焦虑抑郁症 退行性神经症
2020
Language中文
DOI10.13381/j.cnki.cjm.202003024
Source Publication中国微生态学杂志
ISSN1005-376X
Volume32Issue:3Pages:352-357,363
Subtype实证研究
Indexed ByCSCD
Project Intro.

国家重点研发计划项目(2017YFC0822502)

CSCD IDCSCD:6704941
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32035
Collection认知与发展心理学研究室
Affiliation1.中国科学院心理研究所脑与认知科学国家重点实验室
2.中国科学院大学心理学系
3.北京中生金域诊断技术股份有限公司研发部
First Author Affilication脑与认知科学国家重点实验室
Recommended Citation
GB/T 7714
杨路,董婷婷,凌燕,等. 肠道屏障损伤及细菌移位在焦虑抑郁症诱导退行性神经症中的机制[J]. 中国微生态学杂志,2020,32(3):352-357,363.
APA 杨路,董婷婷,凌燕,吕艳霞,&禤宇明.(2020).肠道屏障损伤及细菌移位在焦虑抑郁症诱导退行性神经症中的机制.中国微生态学杂志,32(3),352-357,363.
MLA 杨路,et al."肠道屏障损伤及细菌移位在焦虑抑郁症诱导退行性神经症中的机制".中国微生态学杂志 32.3(2020):352-357,363.
Files in This Item:
File Name/Size DocType Version Access License
肠道屏障损伤及细菌移位在焦虑抑郁症诱导退(620KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[杨路]'s Articles
[董婷婷]'s Articles
[凌燕]'s Articles
Baidu academic
Similar articles in Baidu academic
[杨路]'s Articles
[董婷婷]'s Articles
[凌燕]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[杨路]'s Articles
[董婷婷]'s Articles
[凌燕]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.