Institutional Repository of Key Laboratory of Mental Health, CAS
Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia | |
Gao, Jie1; Xiu, Mei Hong2; Liu, Dian Ying3; Wei, Chang Wei4; Zhang, Xiangyang5 | |
第一作者 | Gao, Jie |
通讯作者邮箱 | zhangxy@psych.ac.cn (xiang yang zhang ) ; wangwei.wei@ccmu.edu.cn |
心理所单位排序 | 5 |
摘要 | The etiology of schizophrenia is still unknown, and the MTHFR gene has been shown to be associated with SCZ. Previous studies have shown that patients with schizophrenia exhibit sex differences in symptoms and cognitive function. However, no study has been conducted to investigate the sex difference in the association between C677T polymorphism and symptoms and cognitive impairment in Chinese patients with schizophrenia. The C677T polymorphism was genotyped in 957 patients with schizophrenia and 576 controls. Patients were also rated on the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The results showed that there were significant differences in MTHFR C677T genotype and allele distributions between male patients and male controls (both p<0.05), while there was no significant difference between female patients and female controls (both p>0.05). Further analysis showed that there were significant sex differences in the association between C677T genotype and negative symptoms, immediate memory or attention index score in schizophrenia (p<0.05). This study suggests that the complex interactive effect between MTHFR C677T polymorphism and sex plays an important role in some clinical characteristics of patients with schizophrenia. |
关键词 | schizophrenia symptoms cognition MTHFR polymorphism |
2020-06-15 | |
DOI | 10.18632/aging.103248 |
发表期刊 | AGING-US |
ISSN | 1945-4589 |
卷号 | 12期号:11页码:10290-10299 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] ; Beijing Natural Science Foundation[7194270] ; Beijing Hospitals Authority Youth Programme[QML20190307] |
项目简介 | National Natural Science Foundation of China;Beijing Natural Science Foundation;Beijing Hospitals Authority Youth Programme |
出版者 | IMPACT JOURNALS LLC |
WOS关键词 | GENDER-DIFFERENCES ; BIPOLAR DISORDER ; EXECUTIVE FUNCTION ; GENE POLYMORPHISM ; NEGATIVE SYMPTOMS ; DNA METHYLATION ; HOMOCYSTEINE ; ASSOCIATION ; FOLATE ; BRAIN |
WOS研究方向 | Cell Biology ; Geriatrics & Gerontology |
WOS类目 | Cell Biology ; Geriatrics & Gerontology |
WOS记录号 | WOS:000540580800022 |
资助机构 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Hospitals Authority Youth Programme |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32076 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wei, Chang Wei; Zhang, Xiangyang |
作者单位 | 1.Capital Med Univ, Beijing Chao Yang Hosp, Dept Cardiac Surg, Beijing, Peoples R China 2.Peking Univ, HuiLongGuan Clin Med Sch, Beijing HuiLongGuan Hosp, Beijing, Peoples R China 3.Third Peoples Hosp Ganzhou, Dept Psychiat, Ganzhou, Jiangxi, Peoples R China 4.Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Gao, Jie,Xiu, Mei Hong,Liu, Dian Ying,et al. Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia[J]. AGING-US,2020,12(11):10290-10299. |
APA | Gao, Jie,Xiu, Mei Hong,Liu, Dian Ying,Wei, Chang Wei,&Zhang, Xiangyang.(2020).Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia.AGING-US,12(11),10290-10299. |
MLA | Gao, Jie,et al."Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia".AGING-US 12.11(2020):10290-10299. |
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