PSYCH OpenIR  > 中国科学院心理健康重点实验室
Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia
Gao, Jie1; Xiu, Mei Hong2; Liu, Dian Ying3; Wei, Chang Wei4; Zhang, Xiangyang5
Corresponding AuthorWei, Chang Wei(changwei.wei@ccmu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
AbstractThe etiology of schizophrenia is still unknown, and the MTHFR gene has been shown to be associated with SCZ. Previous studies have shown that patients with schizophrenia exhibit sex differences in symptoms and cognitive function. However, no study has been conducted to investigate the sex difference in the association between C677T polymorphism and symptoms and cognitive impairment in Chinese patients with schizophrenia. The C677T polymorphism was genotyped in 957 patients with schizophrenia and 576 controls. Patients were also rated on the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The results showed that there were significant differences in MTHFR C677T genotype and allele distributions between male patients and male controls (both p<0.05), while there was no significant difference between female patients and female controls (both p>0.05). Further analysis showed that there were significant sex differences in the association between C677T genotype and negative symptoms, immediate memory or attention index score in schizophrenia (p<0.05). This study suggests that the complex interactive effect between MTHFR C677T polymorphism and sex plays an important role in some clinical characteristics of patients with schizophrenia.
Keywordschizophrenia symptoms cognition MTHFR polymorphism
2020-06-15
Language英语
DOI10.18632/aging.103248
Source PublicationAGING-US
ISSN1945-4589
Volume12Issue:11Pages:10290-10299
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] ; Beijing Natural Science Foundation[7194270] ; Beijing Hospitals Authority Youth Programme[QML20190307]
PublisherIMPACT JOURNALS LLC
WOS KeywordGENDER-DIFFERENCES ; BIPOLAR DISORDER ; EXECUTIVE FUNCTION ; GENE POLYMORPHISM ; NEGATIVE SYMPTOMS ; DNA METHYLATION ; HOMOCYSTEINE ; ASSOCIATION ; FOLATE ; BRAIN
WOS Research AreaCell Biology ; Geriatrics & Gerontology
WOS SubjectCell Biology ; Geriatrics & Gerontology
WOS IDWOS:000540580800022
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32076
Collection中国科学院心理健康重点实验室
Corresponding AuthorWei, Chang Wei; Zhang, Xiangyang
Affiliation1.Capital Med Univ, Beijing Chao Yang Hosp, Dept Cardiac Surg, Beijing, Peoples R China
2.Peking Univ, HuiLongGuan Clin Med Sch, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
3.Third Peoples Hosp Ganzhou, Dept Psychiat, Ganzhou, Jiangxi, Peoples R China
4.Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Gao, Jie,Xiu, Mei Hong,Liu, Dian Ying,et al. Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia[J]. AGING-US,2020,12(11):10290-10299.
APA Gao, Jie,Xiu, Mei Hong,Liu, Dian Ying,Wei, Chang Wei,&Zhang, Xiangyang.(2020).Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia.AGING-US,12(11),10290-10299.
MLA Gao, Jie,et al."Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia".AGING-US 12.11(2020):10290-10299.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gao, Jie]'s Articles
[Xiu, Mei Hong]'s Articles
[Liu, Dian Ying]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gao, Jie]'s Articles
[Xiu, Mei Hong]'s Articles
[Liu, Dian Ying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gao, Jie]'s Articles
[Xiu, Mei Hong]'s Articles
[Liu, Dian Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.