健康与遗传心理学研究室知识库

目的:探讨经皮耳迷走神经刺激(taVNS)治疗原发性失眠(PI)的中枢效应机制。方法:纳入PI患者15例,采用治疗前后自身对照的原则,予以taVNS治疗4周,利用静息态功能磁共振技术,采集治疗前后患者的脑核磁数据,通过局部一致性(ReHo)的分析方法,观察taVNS对患者脑区局部一致性的调节作用。结果:PI患者经过taVNS治疗4周后,大脑多个脑区发生局部一致性的改变,其中左侧内侧额上回(t=5.36,P<0.01 )、右侧前扣带回(t=5.36, P<0.01) ReHo值升高,而右侧颞下回(t=-5.19, P<0.01)、双侧颞中回(t=-5.09,P<0.01)、右侧丘脑(t=-4.88,P<0.01 ReHo值降低。结论:taVNS对前额叶、前扣带回、颞叶、丘脑等相关区域功能的调节可能是其治疗PI的中枢效应机制。

To investigate the central mechanism of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of primary insomnia (PI). Methods: Fifteen patients with PI were enrolled in the study. PI subjects were treated with taVNS for 4 weeks according to the principle of self-control before and after treatment. The brain MRI data of patients before and after treatment were collected by resting-state functional MRI scanning. And the regulatory effect of taVNS on local consistency of patients’ brain was observed by ReHo analysis method. Results: After four weeks taVNS treatment, PI patients had functional consistency changes in multiple brain regions. The regional homogeneity (ReHo) value of left medial superior frontal gyrus (t=5.36, P<0.01) and right anterior cingulate gyrus (t=5.36, P<0.01) increased, while the ReHo value of right inferior temporal gyrus (t=-5.19, P<0.01), bilateral sacral gyrus (t=-5.09, P<0.01), and right thalamus (t=-4.88, P<0.01) decreased. Conclusion: The regulation of taVNS on the functions of prefrontal lobes, anterior cingulate gyrus, temporal lobe and thalamus may be the central mechanism of taVNS in the treatment of PI.