Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity

doi:10.1515/tnsci-2020-0118

PSYCH OpenIR > 健康与遗传心理学研究室

	Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity
	Zhang, Yibing 2; Zhao, Yong 3; Ran, Yongwang 4; Guo, Jianyou5 ; Cui, Haifeng 3; Liu, Sha 1
通讯作者	Liu, Sha(JulietteHaydengsx@yahoo.com)
摘要	Background - Sevoflurane, a volatile anesthetic, is known to induce widespread neuronal degeneration and apoptosis. Recently, the stress-inducible protein sestrin 2 and adenosine monophosphate-activated protein kinase (AMPK) have been found to regulate the levels of intracellular reactive oxygen species (ROS) and suppress oxidative stress. Notoginsenoside R1 (NGR1), a saponin isolated from Panax notoginseng, has been shown to exert neuroprotective effects. The effects of NGR1 against neurotoxicity induced by sevoflurane were assessed. Methods - Sprague-Dawley rat pups on postnatal day 7 (PD7) were exposed to sevoflurane (3%) anesthesia for 6 h. NGR1 at doses of 12.5, 25, or 50 mg/kg body weight was orally administered to pups from PD2 to PD7. Results - Pretreatment with NGR1 attenuated sevoflurane-induced generation of ROS and reduced apoptotic cell counts. Western blotting revealed decreased cleaved caspase 3 and Bad and Box pro-apoptotic protein expression. NGR1 substantially upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) expression along with increased heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase1 levels, suggesting Nrf2 signaling activation. Enhanced sestrin-2 and phosphorylated AMPK expression were noticed following NGR1 pretreatment. Conclusion - This study revealed the neuroprotective effects of NGR1 through effective suppression of apoptosis and ROS via regulation of apoptotic proteins and activation of Nrf2/HO-1 and sestrin 2/AMPK signaling cascades.
关键词	5 '-AMP-activated protein kinase neurotoxicity notoginsenoside R1 sevoflurane sestrin-2 reactive oxygen species
	2020
语种	英语
DOI	10.1515/tnsci-2020-0118
发表期刊	TRANSLATIONAL NEUROSCIENCE
ISSN	2081-3856
卷号	11 期号:1 页码:215-226
收录类别	SCI
出版者	SCIENDO
WOS关键词	INDUCED OXIDATIVE STRESS ; PANAX-NOTOGINSENG ; INDUCED NEUROAPOPTOSIS ; SIGNALING PATHWAY ; ANTIOXIDANT ; ACTIVATION ; ISOFLURANE ; EXPOSURE ; SESTRINS ; BRAIN
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000543768900001
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/32135
专题	健康与遗传心理学研究室
通讯作者	Liu, Sha
作者单位	1.Chongqing Med Univ, Sch Tradit Chinese Med, Chongqing 401331, Peoples R China 2.Chongqing Med Univ, Sch Tradit Chinese Med, Comprehens Teaching & Res Off Tradit Chinese Med, Chongqing 401331, Peoples R China 3.China Acad Tradit Chinese Med, Inst Chinese Mat Med, GLP Lab, Beijing 100700, Peoples R China 4.Qianjiang Cent Hosp Chongqing, Dept Radiol, Chongqing 409099, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yibing,Zhao, Yong,Ran, Yongwang,et al. Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity[J]. TRANSLATIONAL NEUROSCIENCE,2020,11(1):215-226.
APA	Zhang, Yibing,Zhao, Yong,Ran, Yongwang,Guo, Jianyou,Cui, Haifeng,&Liu, Sha.(2020).Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity.TRANSLATIONAL NEUROSCIENCE,11(1),215-226.
MLA	Zhang, Yibing,et al."Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity".TRANSLATIONAL NEUROSCIENCE 11.1(2020):215-226.