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Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats | |
Zhao, Cheng-Bo-Wen1; Liu, Jie2; Shi, Jin-Li1; Wang, Shao-Nan1; Ding, Yong-Sheng1; He, Shuai1; Lin, Ming-Xuan1; Luo, Jing1; Jiang, Yi-Nan1; Bian, Li-Hua1; Yao, Zi-Wei1; Li, Qiu-Yu1; Wang, Xiao-Mei1; Guo, Jian-You3 | |
第一作者 | Zhao, Cheng-Bo-Wen |
通讯作者邮箱 | shijl@vip.sina.com ; jian-you guo ; guojy@psych.ac.cn |
心理所单位排序 | 3 |
摘要 | Herb-pairs are the basic units of composition in Chinese herbal formulae, where the bridge linking Chinese medicine and prescription consists of two Chinese medicine herbs. The Suanzaoren-Wuweizi herb-pair (SWHP) is commonly used as a sedative or tranquilizer. SWHP has been demonstrated to exert an antianxiety effect in animal models of anxiety. However, little information about its mechanism is available and the effects of SWHP have not been investigated. This study examined the effects of SWHP on ameliorating anxiety-like behaviors by regulating endocannabinoids system (ECS)-brain-derived neurotrophic factor (BDNF)-extracellular regulated protein kinases (ERK) signaling pathway expression, induced by restraint stress (RS) procedures. The antianxiety effects of SWHP on RS rats were then examined through the open-field test (OF) and the elevated plus maze test (EPM). The concentration of BNDF, ERK1/2, p-ERK1/2, cAMP-response element binding protein (CREB), and p-CREB expression in the prefrontal cortex and hippocampus of the rats was then measured by western blot. The number of positive cells of CB1 and CB2 in the rats' hippocampus CA1 region was measured by immunohistochemistry. These results gave compelling evidence that SWHP could modify anxiety-like behaviors of RS rats through regulation of the ECS-BDNF-ERK signaling pathway. Our study demonstrated that SWHP improved anxiety-like behaviors in RS rat models by regulating the ECS-BDNF-ERK signaling pathway. The findings indicate that SWHP may have a therapeutic application in the RS model of anxiety disorder, which proposes a potential new direction for research into anxiety disorders regarding mechanisms and the development of novel antianxiety drugs. |
2020-06-17 | |
语种 | 英语 |
DOI | 10.1155/2020/2078932 |
发表期刊 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
ISSN | 1741-427X |
卷号 | 2020页码:13 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | Key New Drugs Innovation Project from Ministry of Science and Technology[2012ZX09102201-018] |
出版者 | HINDAWI LTD |
WOS关键词 | TRADITIONAL CHINESE MEDICINE ; CANNABINOID RECEPTOR ; NEUROTROPHIC FACTOR ; PLUS-MAZE ; ANXIETY ; BRAIN ; DISORDER ; BEHAVIOR |
WOS研究方向 | Integrative & Complementary Medicine |
WOS类目 | Integrative & Complementary Medicine |
WOS记录号 | WOS:000546141800002 |
Q分类 | Q3 |
资助机构 | Key New Drugs Innovation Project from Ministry of Science and Technology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32187 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Shi, Jin-Li; Guo, Jian-You |
作者单位 | 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Yangguang South St, Beijing 102488, Peoples R China 2.Capital Inst Pediat, 2 Yabao Rd, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Cheng-Bo-Wen,Liu, Jie,Shi, Jin-Li,et al. Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,2020:13. |
APA | Zhao, Cheng-Bo-Wen.,Liu, Jie.,Shi, Jin-Li.,Wang, Shao-Nan.,Ding, Yong-Sheng.,...&Guo, Jian-You.(2020).Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,13. |
MLA | Zhao, Cheng-Bo-Wen,et al."Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020(2020):13. |
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