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Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats | |
Zhao, Cheng-Bo-Wen1; Liu, Jie2; Shi, Jin-Li1; Wang, Shao-Nan1; Ding, Yong-Sheng1; He, Shuai1; Lin, Ming-Xuan1; Luo, Jing1; Jiang, Yi-Nan1; Bian, Li-Hua1; Yao, Zi-Wei1; Li, Qiu-Yu1; Wang, Xiao-Mei1; Guo, Jian-You3![]() | |
First Author | Zhao, Cheng-Bo-Wen |
Correspondent Email | shijl@vip.sina.com ; jian-you guo ; guojy@psych.ac.cn |
Contribution Rank | 3 |
Abstract | Herb-pairs are the basic units of composition in Chinese herbal formulae, where the bridge linking Chinese medicine and prescription consists of two Chinese medicine herbs. The Suanzaoren-Wuweizi herb-pair (SWHP) is commonly used as a sedative or tranquilizer. SWHP has been demonstrated to exert an antianxiety effect in animal models of anxiety. However, little information about its mechanism is available and the effects of SWHP have not been investigated. This study examined the effects of SWHP on ameliorating anxiety-like behaviors by regulating endocannabinoids system (ECS)-brain-derived neurotrophic factor (BDNF)-extracellular regulated protein kinases (ERK) signaling pathway expression, induced by restraint stress (RS) procedures. The antianxiety effects of SWHP on RS rats were then examined through the open-field test (OF) and the elevated plus maze test (EPM). The concentration of BNDF, ERK1/2, p-ERK1/2, cAMP-response element binding protein (CREB), and p-CREB expression in the prefrontal cortex and hippocampus of the rats was then measured by western blot. The number of positive cells of CB1 and CB2 in the rats' hippocampus CA1 region was measured by immunohistochemistry. These results gave compelling evidence that SWHP could modify anxiety-like behaviors of RS rats through regulation of the ECS-BDNF-ERK signaling pathway. Our study demonstrated that SWHP improved anxiety-like behaviors in RS rat models by regulating the ECS-BDNF-ERK signaling pathway. The findings indicate that SWHP may have a therapeutic application in the RS model of anxiety disorder, which proposes a potential new direction for research into anxiety disorders regarding mechanisms and the development of novel antianxiety drugs. |
2020-06-17 | |
Language | 英语 |
DOI | 10.1155/2020/2078932 |
Source Publication | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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ISSN | 1741-427X |
Volume | 2020Pages:13 |
Subtype | article |
Indexed By | SCI |
Funding Project | Key New Drugs Innovation Project from Ministry of Science and Technology[2012ZX09102201-018] |
Publisher | HINDAWI LTD |
WOS Keyword | TRADITIONAL CHINESE MEDICINE ; CANNABINOID RECEPTOR ; NEUROTROPHIC FACTOR ; PLUS-MAZE ; ANXIETY ; BRAIN ; DISORDER ; BEHAVIOR |
WOS Research Area | Integrative & Complementary Medicine |
WOS Subject | Integrative & Complementary Medicine |
WOS ID | WOS:000546141800002 |
Quartile | Q3 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/32187 |
Collection | 中国科学院心理健康重点实验室 |
Corresponding Author | Shi, Jin-Li; Guo, Jian-You |
Affiliation | 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Yangguang South St, Beijing 102488, Peoples R China 2.Capital Inst Pediat, 2 Yabao Rd, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China |
Recommended Citation GB/T 7714 | Zhao, Cheng-Bo-Wen,Liu, Jie,Shi, Jin-Li,et al. Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,2020:13. |
APA | Zhao, Cheng-Bo-Wen.,Liu, Jie.,Shi, Jin-Li.,Wang, Shao-Nan.,Ding, Yong-Sheng.,...&Guo, Jian-You.(2020).Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,13. |
MLA | Zhao, Cheng-Bo-Wen,et al."Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020(2020):13. |
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