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Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats
Zhao, Cheng-Bo-Wen1; Liu, Jie2; Shi, Jin-Li1; Wang, Shao-Nan1; Ding, Yong-Sheng1; He, Shuai1; Lin, Ming-Xuan1; Luo, Jing1; Jiang, Yi-Nan1; Bian, Li-Hua1; Yao, Zi-Wei1; Li, Qiu-Yu1; Wang, Xiao-Mei1; Guo, Jian-You3
First AuthorZhao, Cheng-Bo-Wen
Correspondent Emailshijl@vip.sina.com ; jian-you guo ; guojy@psych.ac.cn
2020-06-17
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Subtypearticle
Volume2020Pages:13
QuartileQ3
Contribution Rank3
Abstract

Herb-pairs are the basic units of composition in Chinese herbal formulae, where the bridge linking Chinese medicine and prescription consists of two Chinese medicine herbs. The Suanzaoren-Wuweizi herb-pair (SWHP) is commonly used as a sedative or tranquilizer. SWHP has been demonstrated to exert an antianxiety effect in animal models of anxiety. However, little information about its mechanism is available and the effects of SWHP have not been investigated. This study examined the effects of SWHP on ameliorating anxiety-like behaviors by regulating endocannabinoids system (ECS)-brain-derived neurotrophic factor (BDNF)-extracellular regulated protein kinases (ERK) signaling pathway expression, induced by restraint stress (RS) procedures. The antianxiety effects of SWHP on RS rats were then examined through the open-field test (OF) and the elevated plus maze test (EPM). The concentration of BNDF, ERK1/2, p-ERK1/2, cAMP-response element binding protein (CREB), and p-CREB expression in the prefrontal cortex and hippocampus of the rats was then measured by western blot. The number of positive cells of CB1 and CB2 in the rats' hippocampus CA1 region was measured by immunohistochemistry. These results gave compelling evidence that SWHP could modify anxiety-like behaviors of RS rats through regulation of the ECS-BDNF-ERK signaling pathway. Our study demonstrated that SWHP improved anxiety-like behaviors in RS rat models by regulating the ECS-BDNF-ERK signaling pathway. The findings indicate that SWHP may have a therapeutic application in the RS model of anxiety disorder, which proposes a potential new direction for research into anxiety disorders regarding mechanisms and the development of novel antianxiety drugs.

DOI10.1155/2020/2078932
Indexed BySCI
Language英语
Funding OrganizationKey New Drugs Innovation Project from Ministry of Science and Technology
Funding ProjectKey New Drugs Innovation Project from Ministry of Science and Technology[2012ZX09102201-018]
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000546141800002
PublisherHINDAWI LTD
WOS KeywordTRADITIONAL CHINESE MEDICINE ; CANNABINOID RECEPTOR ; NEUROTROPHIC FACTOR ; PLUS-MAZE ; ANXIETY ; BRAIN ; DISORDER ; BEHAVIOR
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32187
Collection中国科学院心理健康重点实验室
Corresponding AuthorShi, Jin-Li; Guo, Jian-You
Affiliation1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Yangguang South St, Beijing 102488, Peoples R China
2.Capital Inst Pediat, 2 Yabao Rd, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Cheng-Bo-Wen,Liu, Jie,Shi, Jin-Li,et al. Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,2020:13.
APA Zhao, Cheng-Bo-Wen.,Liu, Jie.,Shi, Jin-Li.,Wang, Shao-Nan.,Ding, Yong-Sheng.,...&Guo, Jian-You.(2020).Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,13.
MLA Zhao, Cheng-Bo-Wen,et al."Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020(2020):13.
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