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Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality
Li, Yuling1,2; Cao, Zeyuan1,2,3; Wu, Shuang1,2; Wang, Chao1,2; He, Shuchang1,2; Dong, Yan4; Zhang, Xiangyang5
First AuthorLi, Yuling
Correspondent Emailshuchangh@pku.edu.cn ; dong8958@126.com ; zhangxy@psych.ac.cn
2020-07-07
Source PublicationJOURNAL OF SLEEP RESEARCH
ISSN0962-1105
Subtypearticle
Pages10
Contribution Rank5
Abstract

Job stress and the Circadian Locomotor Output Cycles Kaput (CLOCK) gene could affect circadian rhythm and sleep quality. The main aim of our present study was to investigate the association of job stress,CLOCKgene polymorphism and their interaction with sleep quality in a non-clinical Chinese Han population, which has not been reported to date. Using a cross-sectional design, 450 subjects were recruited in Beijing. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and job stress was measured with the Work Stress Scale.CLOCKgene rs11932595 polymorphism was genotyped in 297 blood samples. Correlation analysis showed a close but different association of high job stress with the PSQI and its components. Analysis of variance showed significant main effects of theCLOCKgene rs11932595 polymorphism. G-allele carriers had a higher score in the PSQI, sleep duration, sleep latency and sleep disturbances. Further interaction analyses showed an ordinal interaction on sleep duration, and a disordinal interaction on daytime dysfunction. Specifically, G-allele carriers had poorer sleep duration than AA homozygotes when in high job stress, while the two subgroups displayed similar sleep duration when in low job stress, conforming to the diathesis-stress model. In comparison to G-allele carriers, AA homozygotes experienced less daytime dysfunction when in low job stress whereas more daytime dysfunction when in high job stress, fitting with the differential susceptibility model. As genetic links have been revealed, our investigation might be conducive for elucidating aetiological factors for sleep quality and targets for implementing interventions to attain good sleep quality.

KeywordCLOCKgene daytime dysfunction job stress rs11932595 single-nucleotide polymorphism (SNP) sleep duration
DOI10.1111/jsr.13133
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China
Funding ProjectNational Natural Science Foundation of China[81871060] ; National Natural Science Foundation of China[81571322]
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000545732100001
PublisherWILEY
WOS KeywordENVIRONMENTAL-INFLUENCES ; 3111T/C POLYMORPHISM ; CLOCK GENES ; LIFE EVENTS ; STRESS ; WORK ; DISTURBANCES ; DEPRESSION ; PREFERENCE ; SAMPLE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32190
Collection中国科学院心理健康重点实验室
Corresponding AuthorHe, Shuchang; Dong, Yan; Zhang, Xiangyang
Affiliation1.Peking Univ, Sch Psychol & Cognit Sci, Beijing, Peoples R China
2.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
3.Boston Univ, Bioinformat Program, Boston, MA 02215 USA
4.Renmin Univ China, Dept Psychol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Healthy, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, Yuling,Cao, Zeyuan,Wu, Shuang,et al. Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality[J]. JOURNAL OF SLEEP RESEARCH,2020:10.
APA Li, Yuling.,Cao, Zeyuan.,Wu, Shuang.,Wang, Chao.,He, Shuchang.,...&Zhang, Xiangyang.(2020).Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality.JOURNAL OF SLEEP RESEARCH,10.
MLA Li, Yuling,et al."Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality".JOURNAL OF SLEEP RESEARCH (2020):10.
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