Institutional Repository of Key Laboratory of Mental Health, CAS
Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring | |
Niu, Yunxia1,2,3; Liang, Shan4; Wang, Tao2; Hu, Xu2; Li, Wei2; Wu, Xiaoli2; Jin, Feng2 | |
第一作者 | Niu, Yunxia |
心理所单位排序 | 2 |
摘要 | Introduction Adolescence is a period of heightened susceptibility to anxiety disorders. Probiotic supplementation had a positive impact on reducing anxiety. The maternal microbiome plays an important role in child health outcomes and in the establishment of the offspring microbiome. Few studies have investigated the impact of gestational probiotic supplementation on the offspring's anxiety. Methods The present study examined the impact of prenatalLactobacillus helveticusNS8 supplementation (LAC) on Sprague Dawley rat offspring's anxiety-like behavior. The behaviors tested in the present study include the elevated plus maze (EPM), the open field test (OFT), and prepulse inhibition (PPI). Analyses of variance were utilized. Results (a) The performance of LAC adolescent rats in the EPM was similar to that in the OFT, both of which reflect that LAC caused an antianxiety effect in adolescent offspring rats and the antianxiety effect without sex differences; (b) LAC did not change performance in PPI and did not change the sex and age differences in PPI; and c. LAC decreased the body mass of rat offspring. Conclusion Lactobacillus helveticusNS8 supplementation during gestation might have a moderate antianxiety effect in both males and females (especially adolescents) and be helpful for avoiding excessive body mass. |
关键词 | antianxiety elevated plus maze test gestation Lactobacillus helveticus open field test |
2020-07-17 | |
语种 | 英语 |
DOI | 10.1002/brb3.1714 |
发表期刊 | BRAIN AND BEHAVIOR |
ISSN | 2162-3279 |
页码 | 13 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | NS Bio Japan |
出版者 | WILEY |
WOS关键词 | ELEVATED PLUS-MAZE ; ANXIETY-LIKE BEHAVIOR ; IMPAIRED PREPULSE INHIBITION ; HIGH-FAT DIET ; GUT MICROBIOTA ; BRAIN-DEVELOPMENT ; ACOUSTIC STARTLE ; SEX-DIFFERENCES ; PROBIOTIC SUPPLEMENTATION ; MENTAL-DISORDERS |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS记录号 | WOS:000549326200001 |
Q分类 | Q3 |
资助机构 | NS Bio Japan |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32253 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Jin, Feng |
作者单位 | 1.Tianjin Univ Technol & Educ, Sch Vocat Educ, Tianjin, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Niu, Yunxia,Liang, Shan,Wang, Tao,et al. Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring[J]. BRAIN AND BEHAVIOR,2020:13. |
APA | Niu, Yunxia.,Liang, Shan.,Wang, Tao.,Hu, Xu.,Li, Wei.,...&Jin, Feng.(2020).Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring.BRAIN AND BEHAVIOR,13. |
MLA | Niu, Yunxia,et al."Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring".BRAIN AND BEHAVIOR (2020):13. |
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