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Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring
Niu, Yunxia1,2,3; Liang, Shan4; Wang, Tao2; Hu, Xu2; Li, Wei2; Wu, Xiaoli2; Jin, Feng2
First AuthorNiu, Yunxia
Contribution Rank2
Abstract

Introduction Adolescence is a period of heightened susceptibility to anxiety disorders. Probiotic supplementation had a positive impact on reducing anxiety. The maternal microbiome plays an important role in child health outcomes and in the establishment of the offspring microbiome. Few studies have investigated the impact of gestational probiotic supplementation on the offspring's anxiety. Methods The present study examined the impact of prenatalLactobacillus helveticusNS8 supplementation (LAC) on Sprague Dawley rat offspring's anxiety-like behavior. The behaviors tested in the present study include the elevated plus maze (EPM), the open field test (OFT), and prepulse inhibition (PPI). Analyses of variance were utilized. Results (a) The performance of LAC adolescent rats in the EPM was similar to that in the OFT, both of which reflect that LAC caused an antianxiety effect in adolescent offspring rats and the antianxiety effect without sex differences; (b) LAC did not change performance in PPI and did not change the sex and age differences in PPI; and c. LAC decreased the body mass of rat offspring. Conclusion Lactobacillus helveticusNS8 supplementation during gestation might have a moderate antianxiety effect in both males and females (especially adolescents) and be helpful for avoiding excessive body mass.

Keywordantianxiety elevated plus maze test gestation Lactobacillus helveticus open field test
2020-07-17
Language英语
DOI10.1002/brb3.1714
Source PublicationBRAIN AND BEHAVIOR
ISSN2162-3279
Pages13
Subtypearticle
Indexed BySCI
Funding ProjectNS Bio Japan
PublisherWILEY
WOS KeywordELEVATED PLUS-MAZE ; ANXIETY-LIKE BEHAVIOR ; IMPAIRED PREPULSE INHIBITION ; HIGH-FAT DIET ; GUT MICROBIOTA ; BRAIN-DEVELOPMENT ; ACOUSTIC STARTLE ; SEX-DIFFERENCES ; PROBIOTIC SUPPLEMENTATION ; MENTAL-DISORDERS
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000549326200001
QuartileQ3
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32253
Collection中国科学院心理健康重点实验室
Corresponding AuthorJin, Feng
Affiliation1.Tianjin Univ Technol & Educ, Sch Vocat Educ, Tianjin, Peoples R China
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Niu, Yunxia,Liang, Shan,Wang, Tao,et al. Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring[J]. BRAIN AND BEHAVIOR,2020:13.
APA Niu, Yunxia.,Liang, Shan.,Wang, Tao.,Hu, Xu.,Li, Wei.,...&Jin, Feng.(2020).Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring.BRAIN AND BEHAVIOR,13.
MLA Niu, Yunxia,et al."Pre-Gestational intake ofLactobacillus helveticusNS8 has anxiolytic effects in adolescent Sprague Dawley offspring".BRAIN AND BEHAVIOR (2020):13.
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