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The Age-related Neural Strategy Alterations in Decision Making Under Risk
Peng, Xue-rui1; Lei, Xu1; Xu, Peng3; Yu, Jing1,2
First AuthorPeng, Xue-rui
Correspondent Emailhelen12@swu.edu.cn (j. yu)
2020-08-01
Source PublicationNEUROSCIENCE
ISSN0306-4522
Subtypearticle
Volume440Pages:30-38
QuartileQ2
Contribution Rank2
Abstract

Previous studies have shown that aging is associated with changes in decision behavior. However, the neural mechanisms that underpin such age differences are inadequately understood. In this study, we aim to characterize the optimal neural model underlying a dynamic decision making task in both young and older adults, and further examine the age differences from the perspective of effective connectivity. Twenty-five young and 23 older adults performed a dynamic risk taking task, i.e., the balloon analogue risk task, in the functional magnetic resonance imaging scanner. The dynamic causal modeling analysis, with the coupling between the ventromedial prefrontal cortex (VMPFC), dorsolateral prefrontal cortex (DLPFC) and anterior insula (AI) that were identified in our task-related activation and psychophysiological interaction analysis, was performed to address the best fitting neural model and characterize age differences. Although both age groups adopted the same optimal model with bidirectional connection between the VMPFC and DLPFC, older adults exhibited up-regulation in several connections and among which the increased modulatory effect of AI-to-VMPFC subserving their decision quality. Our finding suggests that older adults might utilize different neural strategy via compensation to counteract the impact of advanced age in risk taking process. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Keyworddecision making aging dynamic causal modeling effective connectivity compensation
DOI10.1016/j.neuroscience.2020.05.017
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Ministry of Education of Humanities and Social Science ; CAS Key Laboratory of Mental Health, Institute of Psychology
Funding ProjectNational Natural Science Foundation of China[31971007] ; National Natural Science Foundation of China[71942004] ; National Natural Science Foundation of China[6191101096] ; National Natural Science Foundation of China[31971028] ; Ministry of Education of Humanities and Social Science[17YJA190015] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K02]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000548076800003
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordVENTROMEDIAL PREFRONTAL CORTEX ; OLDER-ADULTS ; BRAIN ; ARCHITECTURE ; INSULA ; VOLUME ; DAMAGE ; VMPFC ; FMRI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32262
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Jing
Affiliation1.Southwest Univ, Fac Psychol, Tiansheng Rd, Chongqing 400715, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 610054, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Peng, Xue-rui,Lei, Xu,Xu, Peng,et al. The Age-related Neural Strategy Alterations in Decision Making Under Risk[J]. NEUROSCIENCE,2020,440:30-38.
APA Peng, Xue-rui,Lei, Xu,Xu, Peng,&Yu, Jing.(2020).The Age-related Neural Strategy Alterations in Decision Making Under Risk.NEUROSCIENCE,440,30-38.
MLA Peng, Xue-rui,et al."The Age-related Neural Strategy Alterations in Decision Making Under Risk".NEUROSCIENCE 440(2020):30-38.
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