Institutional Repository of Key Laboratory of Mental Health, CAS
The Age-related Neural Strategy Alterations in Decision Making Under Risk | |
Peng, Xue-rui1; Lei, Xu1; Xu, Peng3; Yu, Jing1,2![]() | |
First Author | Peng, Xue-rui |
Correspondent Email | helen12@swu.edu.cn (j. yu) |
Contribution Rank | 2 |
Abstract | Previous studies have shown that aging is associated with changes in decision behavior. However, the neural mechanisms that underpin such age differences are inadequately understood. In this study, we aim to characterize the optimal neural model underlying a dynamic decision making task in both young and older adults, and further examine the age differences from the perspective of effective connectivity. Twenty-five young and 23 older adults performed a dynamic risk taking task, i.e., the balloon analogue risk task, in the functional magnetic resonance imaging scanner. The dynamic causal modeling analysis, with the coupling between the ventromedial prefrontal cortex (VMPFC), dorsolateral prefrontal cortex (DLPFC) and anterior insula (AI) that were identified in our task-related activation and psychophysiological interaction analysis, was performed to address the best fitting neural model and characterize age differences. Although both age groups adopted the same optimal model with bidirectional connection between the VMPFC and DLPFC, older adults exhibited up-regulation in several connections and among which the increased modulatory effect of AI-to-VMPFC subserving their decision quality. Our finding suggests that older adults might utilize different neural strategy via compensation to counteract the impact of advanced age in risk taking process. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved. |
Keyword | decision making aging dynamic causal modeling effective connectivity compensation |
2020-08-01 | |
Language | 英语 |
DOI | 10.1016/j.neuroscience.2020.05.017 |
Source Publication | NEUROSCIENCE
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ISSN | 0306-4522 |
Volume | 440Pages:30-38 |
Subtype | article |
Indexed By | SCI |
Funding Project | National Natural Science Foundation of China[31971007] ; National Natural Science Foundation of China[71942004] ; National Natural Science Foundation of China[6191101096] ; National Natural Science Foundation of China[31971028] ; Ministry of Education of Humanities and Social Science[17YJA190015] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K02] |
Publisher | PERGAMON-ELSEVIER SCIENCE LTD |
WOS Keyword | VENTROMEDIAL PREFRONTAL CORTEX ; OLDER-ADULTS ; BRAIN ; ARCHITECTURE ; INSULA ; VOLUME ; DAMAGE ; VMPFC ; FMRI |
WOS Research Area | Neurosciences & Neurology |
WOS Subject | Neurosciences |
WOS ID | WOS:000548076800003 |
Quartile | Q2 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/32262 |
Collection | 中国科学院心理健康重点实验室 |
Corresponding Author | Yu, Jing |
Affiliation | 1.Southwest Univ, Fac Psychol, Tiansheng Rd, Chongqing 400715, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 610054, Peoples R China |
Corresponding Author Affilication | Key Laboratory of Mental Health, CAS |
Recommended Citation GB/T 7714 | Peng, Xue-rui,Lei, Xu,Xu, Peng,et al. The Age-related Neural Strategy Alterations in Decision Making Under Risk[J]. NEUROSCIENCE,2020,440:30-38. |
APA | Peng, Xue-rui,Lei, Xu,Xu, Peng,&Yu, Jing.(2020).The Age-related Neural Strategy Alterations in Decision Making Under Risk.NEUROSCIENCE,440,30-38. |
MLA | Peng, Xue-rui,et al."The Age-related Neural Strategy Alterations in Decision Making Under Risk".NEUROSCIENCE 440(2020):30-38. |
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File Name/Size | DocType | Version | Access | License | ||
The Age-related Neur(1128KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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