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Repetitive Transcranial Magnetic Stimulation Improved Source Memory and Modulated Recollection-Based Retrieval in Healthy Older Adults
Cui, Xiaoyu1,2; Ren, Weicong1,2,3; Zheng, Zhiwei1,2; Li, Juan1,2,4
First AuthorCui, Xiaoyu
Correspondent Emailjuan li lijuan@psych.ac.cn
2020-06-19
Source PublicationFRONTIERS IN PSYCHOLOGY
ISSN1664-1078
Subtypearticle
Volume11Pages:15
Contribution Rank1
Abstract

Source memory is one of the cognitive abilities that are most vulnerable to aging. Luckily, the brain plasticity could be modulated to counteract the decline. The repetitive transcranial magnetic stimulation (rTMS), a relatively non-invasive neuro-modulatory technique, could directly modulate neural excitability in the targeted cortical areas. Here, we are interested in whether the application of rTMS could enhance the source memory performance in healthy older adults. In addition, event-related potentials (ERPs) were employed to explore the specific retrieval process that rTMS could affect. Subjects were randomly assigned to either the rTMS group or the sham group. The rTMS group received 10 sessions (20 min per session) of 10 Hz rTMS applying on the right dorsolateral prefrontal cortex (i.e., F4 site), and the sham group received 10 sessions of sham stimulation. Both groups performed source memory tests before and after the intervention while the electroencephalogram (EEG) was recorded during the retrieval process. Behavioral results showed that the source memory performance was significantly improved after rTMS compared with the sham stimulation; ERPs results showed that during the retrieval phase, the left parietal old/new effect, which reflected the process of recollection common to both young and old adults, increased in the rTMS group compared with the sham stimulation group, whereas the late reversed old/new effect specific to the source retrieval of older adults showed similar attenuation after intervention in both groups. The present results suggested that rTMS could be an effective intervention to improve source memory performance in healthy older adults and that it selectively facilitated the youth-like recollection process during retrieval. This study was registered in the Chinese Clinical Trial Registry (ChiCTR) with the identifier chictr-ire-15006371.

Keywordolder adults source memory repetitive transcranial magnetic stimulation recollection event-related potentials
DOI10.3389/fpsyg.2020.01137
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission
Funding ProjectNational Key Research and Development Program of China[2018YFC2001700] ; National Key Research and Development Program of China[2018YFC2000303] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2017YFB1401203] ; National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31700974] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[31861133011] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020089] ; Beijing Municipal Science & Technology Commission[Z171100008217006] ; Beijing Municipal Science & Technology Commission[Z171100000117006]
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000548394700001
PublisherFRONTIERS MEDIA SA
WOS KeywordNONINVASIVE BRAIN-STIMULATION ; ASSOCIATIVE RECOGNITION MEMORY ; MILD COGNITIVE IMPAIRMENT ; LATE POSTERIOR NEGATIVITY ; EPISODIC MEMORY ; ELECTROPHYSIOLOGICAL EVIDENCE ; ALZHEIMERS-DISEASE ; PREFRONTAL CORTEX ; AGE-DIFFERENCES ; AGING BRAIN
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32269
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Juan
Affiliation1.Chinese Acad Sci, Ctr Aging Psychol Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Hebei Normal Univ, Dept Psychol, Shijiazhuang, Hebei, Peoples R China
4.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Cui, Xiaoyu,Ren, Weicong,Zheng, Zhiwei,et al. Repetitive Transcranial Magnetic Stimulation Improved Source Memory and Modulated Recollection-Based Retrieval in Healthy Older Adults[J]. FRONTIERS IN PSYCHOLOGY,2020,11:15.
APA Cui, Xiaoyu,Ren, Weicong,Zheng, Zhiwei,&Li, Juan.(2020).Repetitive Transcranial Magnetic Stimulation Improved Source Memory and Modulated Recollection-Based Retrieval in Healthy Older Adults.FRONTIERS IN PSYCHOLOGY,11,15.
MLA Cui, Xiaoyu,et al."Repetitive Transcranial Magnetic Stimulation Improved Source Memory and Modulated Recollection-Based Retrieval in Healthy Older Adults".FRONTIERS IN PSYCHOLOGY 11(2020):15.
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