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Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies
Wei, Ze-Xu1; Chen, Lei1; Zhang, Jian-Jun2,3; Cheng, Yong1
第一作者Wei, Ze-Xu
通讯作者邮箱zhangjj@psych.ac.cn ; yongcheng@muc.edu.cn
心理所单位排序2
摘要

Aims To characterize the peripheral inflammatory cytokine profile in people with substance use disorders (SUDs). Design Systematic review and meta-analysis. Setting Clinical studies that evaluated peripheral blood inflammatory cytokine levels in patients with SUDs and healthy controls Participants SUD patients and healthy controls. Measurements PubMed and Web of Science were systematically searched for relevant studies. Two investigators independently selected studies and extracted data. A total of 77 articles were included in the meta-analysis, containing 5649 patients with SUDs and 4643 healthy controls. Data were pooled using a random-effects model by the Comprehensive Meta-Analysis version 2 software. Findings Concentrations of interleukin (IL)-6) in 32 studies, tumor necrosis factor (TNF)-alpha in 28 studies, IL-10 in 20 studies, IL-8 in 17 studies, C-reactive protein in 14 studies, IL-4 in 10 studies, IL-12 in seven studies, monocyte chemoattractant protein (MCP)-1 in 6 studies, TNF-receptor 2 (TNF-R2) in four studies and granulocyte-macrophage colony-stimulating factor (GM-CSF) in three studies were significantly higher in patients with SUDs compared with healthy controls, while concentrations of leptin in 14 studies were significantly lower in patients with SUDs compared with healthy controls. The findings were inconclusive for the associations between interferon-gamma, IL-1 beta, IL-2, IL-1 receptor antagonist (IL-1RA), transforming growth factor (TGF)-beta 1, G-CSF, C-C motif chemokine 11, TGF-alpha and SUDs. Conclusions People with substance use disorders (SUDs) appear to have higher peripheral concentrations of IL-4, IL-6, IL-8, IL-10, IL-12, TNF-alpha, C-reactive protein, MCP-1, TNF-R2 and GM-CSF and lower peripheral concentrations of leptin than people without SUDs. This strengthens the view that SUD is accompanied by an inflammatory response.

关键词Cytokines inflammatory response meta-analysis peripheral blood substance use disorder systematic review
2020-07-18
语种英语
DOI10.1111/add.15160
发表期刊ADDICTION
ISSN0965-2140
页码11
期刊论文类型article
收录类别SCI
资助项目National Natural Science Foundation of China[31871111] ; National Natural Science Foundation of China[31400880] ; National Natural Science Foundation of China[81703492] ; Natural Science Foundation of Beijing Municipality[7182092] ; Minzu University Research Fund[2018CXTD03] ; MUC 111 project ; Key Laboratory of Mental Health, Institute of Psychology, CAS
出版者WILEY
WOS关键词NEUROIMMUNE ACTIVATION ; PLACE PREFERENCE ; BINGE DRINKING ; METHAMPHETAMINE ; LEPTIN ; ALCOHOL ; BRAIN ; SAIKOSAPONIN ; MECHANISMS ; EXPRESSION
WOS研究方向Substance Abuse ; Psychiatry
WOS类目Substance Abuse ; Psychiatry
WOS记录号WOS:000549411800001
Q分类Q1
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; Minzu University Research Fund ; MUC 111 project ; Key Laboratory of Mental Health, Institute of Psychology, CAS
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/32272
专题中国科学院心理健康重点实验室
通讯作者Zhang, Jian-Jun; Cheng, Yong
作者单位1.Minzu Univ China, Key Lab Ethnomed, Ctr Translat Neurosci, Minist Educ,Coll Life & Environm Sci, 27 South Zhongguancun Ave, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
通讯作者单位中国科学院心理健康重点实验室
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GB/T 7714
Wei, Ze-Xu,Chen, Lei,Zhang, Jian-Jun,et al. Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies[J]. ADDICTION,2020:11.
APA Wei, Ze-Xu,Chen, Lei,Zhang, Jian-Jun,&Cheng, Yong.(2020).Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies.ADDICTION,11.
MLA Wei, Ze-Xu,et al."Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies".ADDICTION (2020):11.
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