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Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies
Wei, Ze-Xu1; Chen, Lei1; Zhang, Jian-Jun2,3; Cheng, Yong1
First AuthorWei, Ze-Xu
Correspondent Emailzhangjj@psych.ac.cn ; yongcheng@muc.edu.cn
2020-07-18
Source PublicationADDICTION
ISSN0965-2140
Subtypearticle
Pages11
QuartileQ1
Contribution Rank2
Abstract

Aims To characterize the peripheral inflammatory cytokine profile in people with substance use disorders (SUDs). Design Systematic review and meta-analysis. Setting Clinical studies that evaluated peripheral blood inflammatory cytokine levels in patients with SUDs and healthy controls Participants SUD patients and healthy controls. Measurements PubMed and Web of Science were systematically searched for relevant studies. Two investigators independently selected studies and extracted data. A total of 77 articles were included in the meta-analysis, containing 5649 patients with SUDs and 4643 healthy controls. Data were pooled using a random-effects model by the Comprehensive Meta-Analysis version 2 software. Findings Concentrations of interleukin (IL)-6) in 32 studies, tumor necrosis factor (TNF)-alpha in 28 studies, IL-10 in 20 studies, IL-8 in 17 studies, C-reactive protein in 14 studies, IL-4 in 10 studies, IL-12 in seven studies, monocyte chemoattractant protein (MCP)-1 in 6 studies, TNF-receptor 2 (TNF-R2) in four studies and granulocyte-macrophage colony-stimulating factor (GM-CSF) in three studies were significantly higher in patients with SUDs compared with healthy controls, while concentrations of leptin in 14 studies were significantly lower in patients with SUDs compared with healthy controls. The findings were inconclusive for the associations between interferon-gamma, IL-1 beta, IL-2, IL-1 receptor antagonist (IL-1RA), transforming growth factor (TGF)-beta 1, G-CSF, C-C motif chemokine 11, TGF-alpha and SUDs. Conclusions People with substance use disorders (SUDs) appear to have higher peripheral concentrations of IL-4, IL-6, IL-8, IL-10, IL-12, TNF-alpha, C-reactive protein, MCP-1, TNF-R2 and GM-CSF and lower peripheral concentrations of leptin than people without SUDs. This strengthens the view that SUD is accompanied by an inflammatory response.

KeywordCytokines inflammatory response meta-analysis peripheral blood substance use disorder systematic review
DOI10.1111/add.15160
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; Minzu University Research Fund ; MUC 111 project ; Key Laboratory of Mental Health, Institute of Psychology, CAS
Funding ProjectNational Natural Science Foundation of China[31871111] ; National Natural Science Foundation of China[31400880] ; National Natural Science Foundation of China[81703492] ; Natural Science Foundation of Beijing Municipality[7182092] ; Minzu University Research Fund[2018CXTD03] ; MUC 111 project ; Key Laboratory of Mental Health, Institute of Psychology, CAS
WOS Research AreaSubstance Abuse ; Psychiatry
WOS SubjectSubstance Abuse ; Psychiatry
WOS IDWOS:000549411800001
PublisherWILEY
WOS KeywordNEUROIMMUNE ACTIVATION ; PLACE PREFERENCE ; BINGE DRINKING ; METHAMPHETAMINE ; LEPTIN ; ALCOHOL ; BRAIN ; SAIKOSAPONIN ; MECHANISMS ; EXPRESSION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32272
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Jian-Jun; Cheng, Yong
Affiliation1.Minzu Univ China, Key Lab Ethnomed, Ctr Translat Neurosci, Minist Educ,Coll Life & Environm Sci, 27 South Zhongguancun Ave, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wei, Ze-Xu,Chen, Lei,Zhang, Jian-Jun,et al. Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies[J]. ADDICTION,2020:11.
APA Wei, Ze-Xu,Chen, Lei,Zhang, Jian-Jun,&Cheng, Yong.(2020).Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies.ADDICTION,11.
MLA Wei, Ze-Xu,et al."Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies".ADDICTION (2020):11.
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