Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila | |
Yuan, Deliang1,2; Ji, Xiaoxiao1,2; Hao, Shun1,2; Gestrich, Julia Yvonne1; Duan, Wenlan1,2; Wang, Xinwei1,2; Xiang, Yuanhang1,2; Yang, Jihua1,2; Hu, Pengbo1,2; Xu, Mengbo1; Liu, Li1,2,3; Wei, Hongying1,2 | |
第一作者 | Yuan, Deliang |
通讯作者邮箱 | liuli@ibp.ac.cn ; weihongying@ ibp.ac.cn |
心理所单位排序 | 3 |
摘要 | Natural scenes contain complex visual cues with specific features, including color, motion, flicker, and position. It is critical to understand how different visual features are processed at the early stages of visual perception to elicit appropriate cellular responses, and even behavioral output. Here, we studied the visual orientation response induced by flickering stripes in a novel behavioral paradigm in Drosophila melanogaster. We found that free walking flies exhibited bandpass orientation response to flickering stripes of different frequencies. The most sensitive frequency spectrum was confined to low frequencies of 2-4 Hz. Through genetic silencing, we showed that lamina L1 and L2 neurons, which receive visual inputs from R1 to R6 neurons, were the main components in mediating flicker-induced orientation behavior. Moreover, specific blocking of different types of lamina feedback neurons Lawf1, Lawf2, C2, C3, and T1 modulated orientation responses to flickering stripes of particular frequencies, suggesting that bandpass orientation response was generated through cooperative modulation of lamina feedback neurons. Furthermore, we found that lamina feedback neurons Lawf1 were glutamatergic. Thermal activation of Lawf1 neurons could suppress neural activities in L1 and L2 neurons, which could be blocked by the glutamate-gated chloride channel inhibitor picrotoxin (PTX). In summary, lamina monopolar neurons L1 and L2 are the primary components in mediating flicker-induced orientation response. Meanwhile, lamina feedback neurons cooperatively modulate the orientation response in a frequency-dependent way, which might be achieved through modulating neural activities of L1 and L2 neurons. |
关键词 | bandpass response Drosophila feedback neurons flicker-induced orientation frequency |
2020-06-25 | |
语种 | 英语 |
DOI | 10.1111/jnc.15036 |
发表期刊 | JOURNAL OF NEUROCHEMISTRY |
ISSN | 0022-3042 |
页码 | 17 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31800867] ; National Natural Science Foundation of China[31871046] ; National Natural Science Foundation of China[91632107] ; Chinese Academy of Sciences[QYZDY-SSW-SMC015] ; Chinese Academy of Sciences[XDB02040002] ; Beijing Advanced Discipline Fund |
出版者 | WILEY |
WOS关键词 | VISUAL ORIENTATION ; GANGLION-CELLS ; WALKING FLY ; SENSITIVITY ; EXPRESSION ; GLUTAMATE ; HISTAMINE ; FIXATION ; BEHAVIOR ; CHANNEL |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences |
WOS记录号 | WOS:000552837300001 |
Q分类 | Q2 |
资助机构 | National Natural Science Foundation of China ; Chinese Academy of Sciences ; Beijing Advanced Discipline Fund |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32291 |
专题 | 脑与认知科学国家重点实验室 |
通讯作者 | Yuan, Deliang; Wei, Hongying |
作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
第一作者单位 | 脑与认知科学国家重点实验室 |
通讯作者单位 | 脑与认知科学国家重点实验室 |
推荐引用方式 GB/T 7714 | Yuan, Deliang,Ji, Xiaoxiao,Hao, Shun,et al. Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila[J]. JOURNAL OF NEUROCHEMISTRY,2020:17. |
APA | Yuan, Deliang.,Ji, Xiaoxiao.,Hao, Shun.,Gestrich, Julia Yvonne.,Duan, Wenlan.,...&Wei, Hongying.(2020).Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila.JOURNAL OF NEUROCHEMISTRY,17. |
MLA | Yuan, Deliang,et al."Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila".JOURNAL OF NEUROCHEMISTRY (2020):17. |
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