PSYCH OpenIR  > 脑与认知科学国家重点实验室
Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila
Yuan, Deliang1,2; Ji, Xiaoxiao1,2; Hao, Shun1,2; Gestrich, Julia Yvonne1; Duan, Wenlan1,2; Wang, Xinwei1,2; Xiang, Yuanhang1,2; Yang, Jihua1,2; Hu, Pengbo1,2; Xu, Mengbo1; Liu, Li1,2,3; Wei, Hongying1,2
First AuthorYuan, Deliang
Correspondent Emailliuli@ibp.ac.cn ; weihongying@ ibp.ac.cn
2020-06-25
Source PublicationJOURNAL OF NEUROCHEMISTRY
ISSN0022-3042
Subtypearticle
Pages17
QuartileQ2
Contribution Rank3
Abstract

Natural scenes contain complex visual cues with specific features, including color, motion, flicker, and position. It is critical to understand how different visual features are processed at the early stages of visual perception to elicit appropriate cellular responses, and even behavioral output. Here, we studied the visual orientation response induced by flickering stripes in a novel behavioral paradigm in Drosophila melanogaster. We found that free walking flies exhibited bandpass orientation response to flickering stripes of different frequencies. The most sensitive frequency spectrum was confined to low frequencies of 2-4 Hz. Through genetic silencing, we showed that lamina L1 and L2 neurons, which receive visual inputs from R1 to R6 neurons, were the main components in mediating flicker-induced orientation behavior. Moreover, specific blocking of different types of lamina feedback neurons Lawf1, Lawf2, C2, C3, and T1 modulated orientation responses to flickering stripes of particular frequencies, suggesting that bandpass orientation response was generated through cooperative modulation of lamina feedback neurons. Furthermore, we found that lamina feedback neurons Lawf1 were glutamatergic. Thermal activation of Lawf1 neurons could suppress neural activities in L1 and L2 neurons, which could be blocked by the glutamate-gated chloride channel inhibitor picrotoxin (PTX). In summary, lamina monopolar neurons L1 and L2 are the primary components in mediating flicker-induced orientation response. Meanwhile, lamina feedback neurons cooperatively modulate the orientation response in a frequency-dependent way, which might be achieved through modulating neural activities of L1 and L2 neurons.

Keywordbandpass response Drosophila feedback neurons flicker-induced orientation frequency
DOI10.1111/jnc.15036
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Chinese Academy of Sciences ; Beijing Advanced Discipline Fund
Funding ProjectNational Natural Science Foundation of China[31800867] ; National Natural Science Foundation of China[31871046] ; National Natural Science Foundation of China[91632107] ; Chinese Academy of Sciences[QYZDY-SSW-SMC015] ; Chinese Academy of Sciences[XDB02040002] ; Beijing Advanced Discipline Fund
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences
WOS IDWOS:000552837300001
PublisherWILEY
WOS KeywordVISUAL ORIENTATION ; GANGLION-CELLS ; WALKING FLY ; SENSITIVITY ; EXPRESSION ; GLUTAMATE ; HISTAMINE ; FIXATION ; BEHAVIOR ; CHANNEL
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32291
Collection脑与认知科学国家重点实验室
Corresponding AuthorYuan, Deliang; Wei, Hongying
Affiliation1.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Deliang,Ji, Xiaoxiao,Hao, Shun,et al. Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila[J]. JOURNAL OF NEUROCHEMISTRY,2020:17.
APA Yuan, Deliang.,Ji, Xiaoxiao.,Hao, Shun.,Gestrich, Julia Yvonne.,Duan, Wenlan.,...&Wei, Hongying.(2020).Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila.JOURNAL OF NEUROCHEMISTRY,17.
MLA Yuan, Deliang,et al."Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila".JOURNAL OF NEUROCHEMISTRY (2020):17.
Files in This Item:
File Name/Size DocType Version Access License
Lamina feedback neur(2451KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuan, Deliang]'s Articles
[Ji, Xiaoxiao]'s Articles
[Hao, Shun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuan, Deliang]'s Articles
[Ji, Xiaoxiao]'s Articles
[Hao, Shun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan, Deliang]'s Articles
[Ji, Xiaoxiao]'s Articles
[Hao, Shun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.