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OFC and its connectivity with amygdala as predictors for future social anxiety in adolescents
Mao, Yu1,2; Zuo, Xi-Nian3; Ding, Cody2,4; Qiu, Jiang1,2
First AuthorMao, Yu
Correspondent Emailzuoxn@psych.ac.cn (x.-n. zuo) ; codydinge@foxmail.com (c. ding) ; qiuj318@swu.edu.cn (j. qiu).
2020-08-01
Source PublicationDEVELOPMENTAL COGNITIVE NEUROSCIENCE
ISSN1878-9293
Subtypearticle
Volume44Pages:8
QuartileQ1
Contribution Rank3
Abstract

Social anxiety is a common problem that usually emerges at puberty, during which great developmental changes occur both in the brain and mental state. However, little is known about the influence of social anxiety on adolescents' brain and behavior. The present study investigated the neural basis of social anxiety using voxel-based morphometry (VBM) and functional connectivity analysis. Then we investigated whether social anxiety is associated with attention bias. Furthermore, we investigated the neural basis of this association. Finally, longitudinal data was used to test if these biomarkers could predict social anxiety. The results indicated that social anxiety is positively associated with the grey matter volume (GMV) of orbital-frontal cortex (OFC), and the functional connectivity (FC) of OFC-amygdala. Mediation analysis revealed that the relationship between social anxiety and attention avoidance is partly mediated by the FC of OFC-amygdala. Finally, the present study demonstrated a close relationship between FC of the OFC-amygdala, the GMV of the OFC and the individual's social anxiety one year later. The present study suggested the aberrant structure of OFC and its connectivity with amygdala as the neural underpinning of social anxiety, which might serve as a compensatory mechanism to decrease attention avoidance and promote effective emotion regulation.

KeywordSocial anxiety Attention bias OFC Amygdala
DOI10.1016/j.dcn.2020.100804
Indexed BySCI
Language英语
Funding OrganizationInnovative Research Project for Postgraduate Student of Chongqing ; National Natural Science Foundation of China ; Project of the National Defense Science and Technology Innovation Special Zone ; Chang Jiang Scholars Program ; National Outstanding Young People Plan ; Program for the Top Young Talents by Chongqing ; Fundamental Research Funds for the Central Universities ; Natural Science Foundation of Chongqing ; Fok Ying Tung Education Foundation ; Research Program Funds of the Collaborative Innovation Center of Assessment toward Basic Education Quality at Beijing Normal University
Funding ProjectInnovative Research Project for Postgraduate Student of Chongqing[CYB19102] ; National Natural Science Foundation of China[31800947] ; National Natural Science Foundation of China[31470981] ; National Natural Science Foundation of China[31571137] ; National Natural Science Foundation of China[31500885] ; National Natural Science Foundation of China[31600878] ; National Natural Science Foundation of China[31771231] ; Project of the National Defense Science and Technology Innovation Special Zone ; Chang Jiang Scholars Program ; National Outstanding Young People Plan ; Program for the Top Young Talents by Chongqing ; Fundamental Research Funds for the Central Universities[SWU1609177] ; Natural Science Foundation of Chongqing[cstc2015jcyjA10106] ; Fok Ying Tung Education Foundation[151023] ; Research Program Funds of the Collaborative Innovation Center of Assessment toward Basic Education Quality at Beijing Normal University
WOS Research AreaPsychology ; Neurosciences & Neurology
WOS SubjectPsychology, Developmental ; Neurosciences
WOS IDWOS:000551294100012
PublisherELSEVIER SCI LTD
WOS KeywordATTENTIONAL BIAS ; ORBITOFRONTAL CORTEX ; EMOTION REGULATION ; PREFRONTAL CORTEX ; DISORDER ; FACES ; CHILDREN ; THREAT ; FEAR ; HYPERACTIVITY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32315
Collection认知与发展心理学研究室
Corresponding AuthorZuo, Xi-Nian; Ding, Cody; Qiu, Jiang
Affiliation1.SWU, Minist Educ, Key Lab Cognit & Personal, Chongqing 400715, Peoples R China
2.Southwest Univ, Dept Psychol, Chongqing 400715, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.Univ Missouri St Louis, Educ Psychol, St Louis, MO USA
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Mao, Yu,Zuo, Xi-Nian,Ding, Cody,et al. OFC and its connectivity with amygdala as predictors for future social anxiety in adolescents[J]. DEVELOPMENTAL COGNITIVE NEUROSCIENCE,2020,44:8.
APA Mao, Yu,Zuo, Xi-Nian,Ding, Cody,&Qiu, Jiang.(2020).OFC and its connectivity with amygdala as predictors for future social anxiety in adolescents.DEVELOPMENTAL COGNITIVE NEUROSCIENCE,44,8.
MLA Mao, Yu,et al."OFC and its connectivity with amygdala as predictors for future social anxiety in adolescents".DEVELOPMENTAL COGNITIVE NEUROSCIENCE 44(2020):8.
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