PSYCH OpenIR  > 中国科学院心理健康重点实验室
Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia
Wei, Shuochi1,2; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Xia, Luyao1,2; Tian, Yang1,2; Dai, Qilong1,2; Zhu, Rongrong1,2; Wang, Wenjia1,2; Chen, Dachun3; Xiu, Meihong3; Wang, Li1,2; Zhang, Xiang Yang1,2
Corresponding AuthorZhang, Xiang Yang(zhangxy@psych.ac.cn)
2020-08-05
Source PublicationPSYCHOPHARMACOLOGY
ISSN0033-3158
Pages8
AbstractBackground Previous studies have shown that patients with schizophrenia have higher smoking rates and worse cognitive function than healthy controls. However, there is no consistent conclusion about the relationship between smoking and cognitive impairment. Objectives The main purpose of this study was to explore the effects of smoking on cognitive function by using MATRICS Cognitive Consensus Battery (MCCB) in Chinese male patients with schizophrenia. Methods There were 164 patients with chronic schizophrenia and 82 healthy controls. All subjects were interviewed about smoking status. The cognitive function was assessed by MCCB and Stroop tests. The Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptoms of the patients. Results Compared with healthy controls, patients had lower MCCB scores in all of its domain scores (allp< 0.05). In the patients, the scores of spatial span test (42.3 +/- 11.6), digital sequence test (42.9 +/- 10.6), and Hopkins Verbal Learning Test (42.2 +/- 10.1) were lower in smokers than those in nonsmokers (allp< 0.05, effect size: 0.28-0.45). Logistic regression analysis showed that the smoking status of the patients was correlated with digital sequence score (p< 0.05, OR = 1.072, 95%CI: 1.013-1.134). Multivariate regression analysis showed that the spatial span total score (beta= - 0.26,t= - 2.74,p< 0.001) was associated with the duration of smoking in patients with schizophrenia. Conclusions Our findings show that smoking patients with chronic schizophrenia exhibit more severe cognitive impairment than nonsmoking patients, especially in working memory and executive function.
KeywordSchizophrenia Smoking Cognitive Nicotine Memory
DOI10.1007/s00213-020-05621-w
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program
Funding ProjectNational Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000556172400001
PublisherSPRINGER
WOS Keyword1ST-EPISODE DRUG-NAIVE ; TOBACCO SMOKING ; OXIDATIVE STRESS ; WORKING-MEMORY ; BATTERY ; METAANALYSIS ; PERFORMANCE ; ABSTINENCE ; HYPOTHESIS ; PSYCHOSIS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32344
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wei, Shuochi,Wang, Dongmei,Wei, Gaoxia,et al. Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia[J]. PSYCHOPHARMACOLOGY,2020:8.
APA Wei, Shuochi.,Wang, Dongmei.,Wei, Gaoxia.,Wang, Jiesi.,Zhou, Huixia.,...&Zhang, Xiang Yang.(2020).Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia.PSYCHOPHARMACOLOGY,8.
MLA Wei, Shuochi,et al."Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia".PSYCHOPHARMACOLOGY (2020):8.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wei, Shuochi]'s Articles
[Wang, Dongmei]'s Articles
[Wei, Gaoxia]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wei, Shuochi]'s Articles
[Wang, Dongmei]'s Articles
[Wei, Gaoxia]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wei, Shuochi]'s Articles
[Wang, Dongmei]'s Articles
[Wei, Gaoxia]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.